Functional subdivision of islets of Langerhans and possible role of D cells - PubMed (original) (raw)
Functional subdivision of islets of Langerhans and possible role of D cells
L Orci et al. Lancet. 1975.
Abstract
Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet--i.e., mostly in its peripheral part--they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.
Similar articles
- Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function.
Hauge-Evans AC, King AJ, Carmignac D, Richardson CC, Robinson IC, Low MJ, Christie MR, Persaud SJ, Jones PM. Hauge-Evans AC, et al. Diabetes. 2009 Feb;58(2):403-11. doi: 10.2337/db08-0792. Epub 2008 Nov 4. Diabetes. 2009. PMID: 18984743 Free PMC article. - Pancreatic somatostatin.
Weir GC, Bonner-Weir S. Weir GC, et al. Adv Exp Med Biol. 1985;188:403-23. doi: 10.1007/978-1-4615-7886-4_22. Adv Exp Med Biol. 1985. PMID: 2863944 Review. - Human pancreatic islet cell clones secreting insulin, glucagon and somatostatin: immunocytochemical and functional studies.
Matsuba I, Tanese T, Abe M. Matsuba I, et al. Arch Histol Jpn. 1982 Feb;45(1):111-9. doi: 10.1679/aohc.45.111. Arch Histol Jpn. 1982. PMID: 6125140 - Somatostatin and diabetes.
Gerich JE. Gerich JE. Am J Med. 1981 Mar;70(3):619-26. doi: 10.1016/0002-9343(81)90584-2. Am J Med. 1981. PMID: 6111219 Review.
Cited by
- Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.
Kothegala L, Miranda C, Singh M, Krieger JP, Gandasi NR. Kothegala L, et al. Int J Mol Sci. 2023 Feb 9;24(4):3449. doi: 10.3390/ijms24043449. Int J Mol Sci. 2023. PMID: 36834860 Free PMC article. - Determinants and dynamics of pancreatic islet architecture.
Adams MT, Blum B. Adams MT, et al. Islets. 2022 Dec 31;14(1):82-100. doi: 10.1080/19382014.2022.2030649. Islets. 2022. PMID: 35258417 Free PMC article. Review. - Shifting Paradigms in the Pathophysiology and Treatment of Carcinoid Crisis.
Maxwell JE, Naraev B, Halperin DM, Choti MA, Halfdanarson TR. Maxwell JE, et al. Ann Surg Oncol. 2022 May;29(5):3072-3084. doi: 10.1245/s10434-022-11371-0. Epub 2022 Feb 14. Ann Surg Oncol. 2022. PMID: 35165817 Review. - Pancreatic β-Cell Development and Regeneration.
Kerper N, Ashe S, Hebrok M. Kerper N, et al. Cold Spring Harb Perspect Biol. 2022 May 27;14(5):a040741. doi: 10.1101/cshperspect.a040741. Cold Spring Harb Perspect Biol. 2022. PMID: 34580120 Free PMC article. Review. - The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.
Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L. Martínez MS, et al. Int J Mol Sci. 2021 Sep 1;22(17):9504. doi: 10.3390/ijms22179504. Int J Mol Sci. 2021. PMID: 34502413 Free PMC article. Review.