The period of susceptibility to the physiological effects of unilateral eye closure in kittens - PubMed (original) (raw)
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
D H Hubel et al. J Physiol. 1970 Feb.
Abstract
1. Kittens were visually deprived by suturing the lids of the right eye for various periods of time at different ages. Recordings were subsequently made from the striate cortex, and responses from the two eyes compared. As previously reported, monocular eye closure during the first few months of life causes a sharp decline in the number of cells that can be influenced by the previously closed eye.2. Susceptibility to the effects of eye closure begins suddenly near the start of the fourth week, remains high until some time between the sixth and eighth weeks, and then declines, disappearing finally around the end of the third month. Monocular closure for over a year in an adult cat produces no detectable effects.3. During the period of high susceptibility in the fourth and fifth weeks eye closure for as little as 3-4 days leads to a sharp decline in the number of cells that can be driven from both eyes, as well as an over-all decline in the relative influence of the previously closed eye. A 6-day closure is enough to give a reduction in the number of cells that can be driven by the closed eye to a fraction of the normal. The physiological picture is similar to that following a 3-month monocular deprivation from birth, in which the proportion of cells the eye can influence drops from 85 to about 7%.4. Cells of the lateral geniculate receiving input from a deprived eye are noticeably smaller and paler to Nissl stain following 3 or 6 days' deprivation during the fourth week.5. Following 3 months of monocular deprivation, opening the eye for up to 5 yr produces only a very limited recovery in the cortical physiology, and no obvious recovery of the geniculate atrophy, even though behaviourally there is some return of vision in the deprived eye. Closing the normal eye, though necessary for behavioural recovery, has no detectable effect on the cortical physiology. The amount of possible recovery in the striate cortex is probably no greater if the period of eye closure is limited to weeks, but after a 5-week closure there is a definite enhancement of the recovery, even though it is far from complete.
Similar articles
- Effect of prior visual experience on cortical recovery from the effects of unilateral eyelid suture in kittens.
Blasdel GG, Pettigrew JD. Blasdel GG, et al. J Physiol. 1978 Jan;274:601-19. doi: 10.1113/jphysiol.1978.sp012169. J Physiol. 1978. PMID: 625011 Free PMC article. - Consequences of monocular deprivation on visual behaviour in kittens.
Dews PB, Wiesel TN. Dews PB, et al. J Physiol. 1970 Feb;206(2):437-55. doi: 10.1113/jphysiol.1970.sp009023. J Physiol. 1970. PMID: 5498494 Free PMC article. - Postcritical-period reversal of effects of monocular deprivation on striate cortex cells in the cat.
Kratz KE, Spear PD. Kratz KE, et al. J Neurophysiol. 1976 May;39(3):501-11. doi: 10.1152/jn.1976.39.3.501. J Neurophysiol. 1976. PMID: 948005 - The rate of recovery of vision after early monocular deprivation in kittens.
Giffin F, Mitchell DE. Giffin F, et al. J Physiol. 1978 Jan;274:511-37. doi: 10.1113/jphysiol.1978.sp012164. J Physiol. 1978. PMID: 625006 Free PMC article. - Reversal of the physiological effects of monocular deprivation in the kitten's visual cortex.
Movshon JA. Movshon JA. J Physiol. 1976 Sep;261(1):125-74. doi: 10.1113/jphysiol.1976.sp011551. J Physiol. 1976. PMID: 994027 Free PMC article.
Cited by
- Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination.
Miller VK, Broadie K. Miller VK, et al. PLoS Biol. 2024 Oct 1;22(10):e3002822. doi: 10.1371/journal.pbio.3002822. eCollection 2024 Oct. PLoS Biol. 2024. PMID: 39352884 Free PMC article. - Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies.
Farooq U, Dragoi G. Farooq U, et al. Nat Commun. 2024 Sep 28;15(1):8417. doi: 10.1038/s41467-024-52758-9. Nat Commun. 2024. PMID: 39341810 Free PMC article. - Perceiving depth beyond sight: Evaluating intrinsic and learned cues via a proof of concept sensory substitution method in the visually impaired and sighted.
Maimon A, Wald IY, Snir A, Ben Oz M, Amedi A. Maimon A, et al. PLoS One. 2024 Sep 25;19(9):e0310033. doi: 10.1371/journal.pone.0310033. eCollection 2024. PLoS One. 2024. PMID: 39321152 Free PMC article. - Disinhibition enables vocal repertoire expansion after a critical period.
Heim F, Mendoza E, Koparkar A, Vallentin D. Heim F, et al. Nat Commun. 2024 Aug 31;15(1):7565. doi: 10.1038/s41467-024-51818-4. Nat Commun. 2024. PMID: 39217170 Free PMC article. - Landolt C-Tests With "Fixed" Arcmin Separations Detect Amblyopia But Underestimate Crowding in Moderate-to-Severe Amblyopic Children and Adults.
Waugh SJ, Fronius M. Waugh SJ, et al. Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):33. doi: 10.1167/iovs.65.10.33. Invest Ophthalmol Vis Sci. 2024. PMID: 39177974 Free PMC article.
References
- J Neurophysiol. 1965 Nov;28(6):1029-40 - PubMed
- J Neurophysiol. 1965 Nov;28(6):1041-59 - PubMed
- J Neurophysiol. 1965 Nov;28(6):1060-72 - PubMed
- Exp Brain Res. 1967;3(4):337-52 - PubMed
- Exp Neurol. 1967 Nov;19(3):331-45 - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous