Effects of ascorbate on leucocytes: Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate - PubMed (original) (raw)
. 1979 Sep 8;56(11):429-33.
- PMID: 550365
Effects of ascorbate on leucocytes: Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate
R Anderson et al. S Afr Med J. 1979.
Abstract
Abnormal in vitro neutrophil motility was found in 10 patients with recurrent bacterial infection. The defect appeared to be primary in 3 patients, secondary to hyperimmunoglobulinaemia E in 2 patients and secondary to bacterial infection in 5 patients. In 7 patients impaired polymorphonuclear leucocyte (PMN) motility was the only detectable abnormality; defective lymphocyte function was found in 2 patients and 1 had a total IgA deficiency. Increased random motility and migration to endotoxin-activated serum (EAS) and partially purified C5a was observed when patients' neutrophils were incubated with 5 x 10(-2)M calcium ascorbate or 10(-1)M sodium ascorbate in the presence of 5% autologous serum in vitro. Six of the patients, 4 children and 2 adults, were given oral ascorbate, 1 g daily for children and 3 g daily for adults, and tests of neutrophil migration were performed at monthly intervals thereafter. Improved neutrophil motility was observed in all patients and this correlated with clinical improvement in 5 of the 6.
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