Metabolism correlates of cocaine-induced stereotypy in rats - PubMed (original) (raw)
Metabolism correlates of cocaine-induced stereotypy in rats
V S Estevez et al. Pharmacol Biochem Behav. 1979 Feb.
Abstract
An increase in stereotyped behavior was observed in rats injected daily with cocaine (40 mg/kg, IP), as compared with the first day. This increase persisted 14 days after discontinuation of the drug treatment, and corresponded to increased levels of 3H-cocaine norcocaine and benzoylecgonine in brain. Pretreatment of the animals with SKF-522A, an inhibitor of cocaine demethylation, produced a decrease in stereotypy rating and concomitantly a lower level of 3H-norcocaine in the brain. The role of this metabolite in the production of cocaine-induced stereotyped behavior is discussed.
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