Animal model of depression - PubMed (original) (raw)
- PMID: 573643
Animal model of depression
R D Porsolt. Biomedicine. 1979 Jul.
Abstract
A behavioural procedure is described which may provide an animal model for some aspects of human depression. Rats or mice when forced to swim in a restricted space will rapidly cease attempts to escape and become immobile. Immobility is reduced by many clinically effective antidepressant treatments suggesting that the immobile behaviour may reflect a state of lowered mood in the animal. If so the method could be useful as a simple experimental tool for research into the biology and therapeutics of depression.
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