Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice - PubMed (original) (raw)

Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice

Y Nishizuka et al. Science. 1969.

Abstract

Neonatal thymectomy of mice, when no ectopic thymus existed, constantly resulted in developmental arrest of the ovary but not of the testis; it also caused sterility in the female. The ovaries of thymectomized mice were extremely small and were characterized by absence of follicles and corpora lutea. Such an ovarian dysgenesia was observed when the mice were thymectomized at 3 days of age, but not at 7 days or later; it was prevented by thymus grafting.

PubMed Disclaimer

Similar articles

• The role of the endocrine thymus in female reproduction.
  Michael SD. Michael SD. Arthritis Rheum. 1979 Nov;22(11):1241-5. doi: 10.1002/art.1780221111. Arthritis Rheum. 1979. PMID: 508374
• Thymus and the endocrine system: ovarian dysgenesis in neonatally thymectomized rats.
  Hattori M, Brandon MR. Hattori M, et al. J Endocrinol. 1979 Oct;83(1):101-11. doi: 10.1677/joe.0.0830101. J Endocrinol. 1979. PMID: 521703
• Effect of neonatal thymectomy on follicle numbers in the post-natal mouse ovary.
  Lintern-Moore S, Norbaek-Sorensen I. Lintern-Moore S, et al. Mech Ageing Dev. 1976 Jul-Aug;5(4):235-9. doi: 10.1016/0047-6374(76)90023-3. Mech Ageing Dev. 1976. PMID: 986522
• Thymic control mechanism in ovarian development: reconstitution of ovarian dysgenesis in thymectomized mice by replacement with thymic and other lymphoid tissues.
  Sakakura T, Nishizuka Y. Sakakura T, et al. Endocrinology. 1972 Feb;90(2):431-7. doi: 10.1210/endo-90-2-431. Endocrinology. 1972. PMID: 5009328 No abstract available.
• [Role of the thymus in differentiation of cells of the lymphoid series].
  Giulling EV. Giulling EV. Fiziol Zh. 1977 Nov-Dec;23(6):847-51. Fiziol Zh. 1977. PMID: 338374 Review. Ukrainian. No abstract available.

Cited by

• Epigenetic regulation of human FOXP3+ Tregs: from homeostasis maintenance to pathogen defense.
  Yue Y, Ren Y, Lu C, Li P, Zhang G. Yue Y, et al. Front Immunol. 2024 Jul 31;15:1444533. doi: 10.3389/fimmu.2024.1444533. eCollection 2024. Front Immunol. 2024. PMID: 39144146 Free PMC article. Review.
• Biomaterial-enhanced treg cell immunotherapy: A promising approach for transplant medicine and autoimmune disease treatment.
  Mashayekhi K, Khazaie K, Faubion WA Jr, Kim GB. Mashayekhi K, et al. Bioact Mater. 2024 Apr 22;37:269-298. doi: 10.1016/j.bioactmat.2024.03.030. eCollection 2024 Jul. Bioact Mater. 2024. PMID: 38694761 Free PMC article. Review.
• Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis.
  Shirafkan F, Hensel L, Rattay K. Shirafkan F, et al. Front Immunol. 2024 Mar 20;15:1339714. doi: 10.3389/fimmu.2024.1339714. eCollection 2024. Front Immunol. 2024. PMID: 38571951 Free PMC article. Review.
• Targeting tumor-infiltrating tregs for improved antitumor responses.
  Qin D, Zhang Y, Shu P, Lei Y, Li X, Wang Y. Qin D, et al. Front Immunol. 2024 Mar 4;15:1325946. doi: 10.3389/fimmu.2024.1325946. eCollection 2024. Front Immunol. 2024. PMID: 38500876 Free PMC article. Review.
• Targeting T regulatory (Treg) cells in immunotherapy-resistant cancers.
  Spiliopoulou P, Kaur P, Hammett T, Di Conza G, Lahn M. Spiliopoulou P, et al. Cancer Drug Resist. 2024 Jan 12;7:2. doi: 10.20517/cdr.2023.46. eCollection 2024. Cancer Drug Resist. 2024. PMID: 38318526 Free PMC article. Review.

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon