Prostaglandin: release from the rat phrenic nerve--diaphragm preparation - PubMed (original) (raw)

Prostaglandin: release from the rat phrenic nerve--diaphragm preparation

P W Ramwell et al. Science. 1965.

Abstract

Release of a substance that stimulates smooth muscle was detected from a phrenic nerve-diaphragm preparation from the rat upon direct and indirect stimulation. On thin-layer chromatography most of the active material behaved as a mixture of prostaglandins. The effect of electrical stimulation was mimicked by catecholamines but not by acetylcholine or eserine. The effect of nerve stimulation was not antagonized by d-tubocurarine.

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