Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes - PubMed (original) (raw)

Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes

J D Levine et al. Science. 1984.

Abstract

Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.

PubMed Disclaimer

Similar articles

• Hyperalgesia onset latency suggests a hierarchy of action.
  Taiwo YO, Goetzl EJ, Levine JD. Taiwo YO, et al. Brain Res. 1987 Oct 13;423(1-2):333-7. doi: 10.1016/0006-8993(87)90858-4. Brain Res. 1987. PMID: 2823989
• Hyperalgesic properties of 15-lipoxygenase products of arachidonic acid.
  Levine JD, Lam D, Taiwo YO, Donatoni P, Goetzl EJ. Levine JD, et al. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5331-4. doi: 10.1073/pnas.83.14.5331. Proc Natl Acad Sci U S A. 1986. PMID: 3014543 Free PMC article.
• [Prostanoids in the physiology and pathology of the cardiovascular system].
  Markov KhM. Markov KhM. Kardiologiia. 1982 Mar;22(3):13-24. Kardiologiia. 1982. PMID: 6281511 Review. Russian. No abstract available.
• [Physiological and pharmacological actions of prostaglandins and related substances on the respiratory system].
  Kohno S, Ohata K. Kohno S, et al. Nihon Rinsho. 1985 Mar;43(3):497-500. Nihon Rinsho. 1985. PMID: 2989582 Review. Japanese. No abstract available.

Cited by

• Analgesic and anti-inflammatory activities of bupropion in animal models.
  Hajhashemi V, Khanjani P. Hajhashemi V, et al. Res Pharm Sci. 2014 Jul-Aug;9(4):251-7. Res Pharm Sci. 2014. PMID: 25657796 Free PMC article.
• The role of neutrophils in neuro-immune modulation.
  Kanashiro A, Hiroki CH, da Fonseca DM, Birbrair A, Ferreira RG, Bassi GS, Fonseca MD, Kusuda R, Cebinelli GCM, da Silva KP, Wanderley CW, Menezes GB, Alves-Fiho JC, Oliveira AG, Cunha TM, Pupo AS, Ulloa L, Cunha FQ. Kanashiro A, et al. Pharmacol Res. 2020 Jan;151:104580. doi: 10.1016/j.phrs.2019.104580. Epub 2019 Nov 28. Pharmacol Res. 2020. PMID: 31786317 Free PMC article. Review.
• Anti-nociceptive and anti-inflammatory activities of aqueous leaves extract of Ocimum gratissimum (Labiate) in rodents.
  Tanko Y, Magaji GM, Yerima M, Magaji RA, Mohammed A. Tanko Y, et al. Afr J Tradit Complement Altern Med. 2008 Jan 22;5(2):141-6. doi: 10.4314/ajtcam.v5i2.31265. Afr J Tradit Complement Altern Med. 2008. PMID: 20161929 Free PMC article.
• Pathogenesis of postoperative oral surgical pain.
  Ong CK, Seymour RA. Ong CK, et al. Anesth Prog. 2003 Winter;50(1):5-17. Anesth Prog. 2003. PMID: 12722900 Free PMC article. Review.
• Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain.
  Hasegawa S, Kohro Y, Shiratori M, Ishii S, Shimizu T, Tsuda M, Inoue K. Hasegawa S, et al. PLoS One. 2010 May 3;5(5):e10467. doi: 10.1371/journal.pone.0010467. PLoS One. 2010. PMID: 20454616 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon