mRNAs from human adenovirus 2 early region 4 - PubMed (original) (raw)

mRNAs from human adenovirus 2 early region 4

A Virtanen et al. J Virol. 1984 Sep.

Abstract

The molecular structure of the mRNAs from early region 4 of human adenovirus 2 has been studied by Northern blot analysis, S1 nuclease analysis, and sequence analysis of cDNA clones. The results make it possible to identify four different splice donor sites and six different splice acceptor sites. The structure of 12 different mRNAs can be deduced from the analysis. The mRNAs have identical 5' and 3' ends and are thus likely to be processed from a common mRNA precursor by differential splicing. The different mRNA species are formed by the removal of one to three introns, and they all carry a short 5' leader segment. The introns appear to serve two functions; they either place a 5' leader segment in juxtaposition with an open reading frame or fuse two open translational reading frames. The early region 4 mRNAs can encode at least seven unique polypeptides.

PubMed Disclaimer

References

    1. J Virol. 1978 Jun;26(3):736-49 - PubMed
    1. J Virol. 1984 Apr;50(1):106-17 - PubMed
    1. Virology. 1978 Oct 1;90(1):67-79 - PubMed
    1. Cell. 1978 Oct;15(2):497-510 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5329-33 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources