Epidermal growth factor receptors in human breast cancer - PubMed (original) (raw)

• PMID: 6091821
• DOI: 10.1007/BF01806484

Epidermal growth factor receptors in human breast cancer

R Pérez et al. Breast Cancer Res Treat. 1984.

Abstract

The capacity for specific binding of 125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demonstrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

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