Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide - PubMed (original) (raw)
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide
A Goldstein et al. Proc Natl Acad Sci U S A. 1981 Nov.
Abstract
The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.
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