Nitrogen control in Pseudomonas aeruginosa: mutants affected in the synthesis of glutamine synthetase, urease, and NADP-dependent glutamate dehydrogenase - PubMed (original) (raw)
Comparative Study
Nitrogen control in Pseudomonas aeruginosa: mutants affected in the synthesis of glutamine synthetase, urease, and NADP-dependent glutamate dehydrogenase
D B Janssen et al. J Bacteriol. 1982 Jul.
Abstract
Mutants were isolated from Pseudomonas aeruginosa that were impaired in the utilization of a number of nitrogen sources. In contrast to the wild-type strain, these mutants appeared to be unable to derepress the formation of glutamine synthetase and urease under nitrogen-limited growth conditions, whereas NADP-dependent glutamate dehydrogenase became derepressed. This GlnR- phenotype appeared to be caused by a mutation located in the early region of the P. aeruginosa PAO chromosomal map, close to hisIV59. Partial suppression of the GlnR- phenotype due to a mutation located close to hisII4 was observed. These revertants were different from both the wild-type strain and the GlnR- mutant with respect to the regulation of the synthesis of glutamine synthetase, urease, and NADP-dependent glutamate dehydrogenase (GlnRc phenotype). Also the regulation of glutamine synthetase activity by adenylylation/deadenylylation was altered in the revertants. The results suggest the presence of a regulatory gene that plays a role in the regulation of enzyme formation in response to the availability of ammonia.
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References
- Arch Microbiol. 1980 Feb;124(2-3):197-203 - PubMed
- J Bacteriol. 1980 Apr;142(1):99-110 - PubMed
- J Gen Microbiol. 1980 Feb;116(2):381-9 - PubMed
- Proc Natl Acad Sci U S A. 1980 May;77(5):2636-40 - PubMed
- J Bacteriol. 1981 Jan;145(1):145-55 - PubMed
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