Intradermal hepatitis B virus vaccine: immunogenicity and side-effects in adults - PubMed (original) (raw)
Comparative Study
Intradermal hepatitis B virus vaccine: immunogenicity and side-effects in adults
K D Miller et al. Lancet. 1983 Dec.
Abstract
Fourteen adult volunteers were given a series of three 0.1 ml (2.0 micrograms of antigen protein) intradermal doses of hepatitis B virus vaccine (Merck). An antibody (anti-HBs) response was induced in 10 of 12 (83%) who were antibody negative at the start of the study. Two participants who had anti-HBs before vaccination had a significant increase in serum antibody. The two participants with no antibody response were the oldest members of the study group. Side-effects of the vaccine were limited to local reactions at the site of administration.
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