Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture - PubMed (original) (raw)

Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture

D Leifer et al. Science. 1984.

Abstract

Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.

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