Karyometric changes in human muscle with age - PubMed (original) (raw)

• PMID: 615717
• DOI: 10.1159/000114877

Karyometric changes in human muscle with age

D Vassilopoulos et al. Eur Neurol. 1977.

Abstract

Human muscle cell growth was studied to investigate the nucleo-cytoplasmic ratio during development and ageing. The mean muscle fibre size, as well as the number and size of myonuclei were estimated in human muscle biopsies from normal individuals whose ages ranged from 1 to 71 years. Changes in muscle fibre size were accompanied by similar changes in nuclear number, the size of which remained the same. This resulted in a constant nucleo-cytoplasmic ratio during the age range studied. The role of the satellite cell in the maintenance of this ratio was discussed.

PubMed Disclaimer

Similar articles

• Nucleo-cytoplasmic ratio in ageing skeletal muscle.
  Manta P, Vassilopoulos D, Spengos M. Manta P, et al. Eur Arch Psychiatry Neurol Sci. 1987;236(4):235-6. doi: 10.1007/BF00383854. Eur Arch Psychiatry Neurol Sci. 1987. PMID: 3582433
• The number of satellite cells in normal human muscle.
  Schmalbruch H, Hellhammer U. Schmalbruch H, et al. Anat Rec. 1976 Jul;185(3):279-87. doi: 10.1002/ar.1091850303. Anat Rec. 1976. PMID: 937735
• Is the myonuclear domain size fixed?
  Van der Meer SF, Jaspers RT, Degens H. Van der Meer SF, et al. J Musculoskelet Neuronal Interact. 2011 Dec;11(4):286-97. J Musculoskelet Neuronal Interact. 2011. PMID: 22130137 Review.
• What determines myonuclear domain size?
  Qaisar R, Larsson L. Qaisar R, et al. Indian J Physiol Pharmacol. 2014 Jan-Mar;58(1):1-12. Indian J Physiol Pharmacol. 2014. PMID: 25464670 Review.

Cited by

• Molecular and Structural Alterations of Skeletal Muscle Tissue Nuclei during Aging.
  Cisterna B, Malatesta M. Cisterna B, et al. Int J Mol Sci. 2024 Feb 2;25(3):1833. doi: 10.3390/ijms25031833. Int J Mol Sci. 2024. PMID: 38339110 Free PMC article. Review.
• Myonuclear permanence in skeletal muscle memory: a systematic review and meta-analysis of human and animal studies.
  Rahmati M, McCarthy JJ, Malakoutinia F. Rahmati M, et al. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2276-2297. doi: 10.1002/jcsm.13043. Epub 2022 Aug 12. J Cachexia Sarcopenia Muscle. 2022. PMID: 35961635 Free PMC article. Review.
• Skeletal muscle fibers count on nuclear numbers for growth.
  Prasad V, Millay DP. Prasad V, et al. Semin Cell Dev Biol. 2021 Nov;119:3-10. doi: 10.1016/j.semcdb.2021.04.015. Epub 2021 May 8. Semin Cell Dev Biol. 2021. PMID: 33972174 Free PMC article. Review.
• Satellite cells in human skeletal muscle; from birth to old age.
  Verdijk LB, Snijders T, Drost M, Delhaas T, Kadi F, van Loon LJ. Verdijk LB, et al. Age (Dordr). 2014 Apr;36(2):545-7. doi: 10.1007/s11357-013-9583-2. Age (Dordr). 2014. PMID: 24122288 Free PMC article.
• The senescent rat diaphragm does not exhibit age-related changes in caspase activities, DNA fragmentation, or myonuclear domain.
  Kavazis AN, DeRuisseau KC, Gordon DM. Kavazis AN, et al. Eur J Appl Physiol. 2012 Dec;112(12):3983-90. doi: 10.1007/s00421-012-2380-2. Epub 2012 Mar 21. Eur J Appl Physiol. 2012. PMID: 22434253

MeSH terms

LinkOut - more resources

• Full Text Sources

  • S. Karger AG, Basel, Switzerland