Monoclonal antibodies specific for simian virus 40 tumor antigens - PubMed (original) (raw)

Monoclonal antibodies specific for simian virus 40 tumor antigens

E Harlow et al. J Virol. 1981 Sep.

Abstract

Thirty hybridomas that secrete immunoglobulins against the simian virus 40 tumor antigens were isolated and cloned. Of these, 28 produced antibodies which bound to simian virus 40 large-T, and 2 produced antibodies which bound to the host 53,000-dalton protein. As in previous work, large-T antigen was found to have at least one determinant that it shared with small-t antigen and to have a minimum of six unique determinants. Several of the monoclonal antibodies from the L series hybridomas recognized determinants that were present on a subset of the large-T antigen from simian virus 40-transformed mouse cells. These monoclonal antibodies should be useful in studies of the structure and function of the simian virus 40 tumor antigens.

PubMed Disclaimer

References

    1. Virology. 1970 May;41(1):22-9 - PubMed
    1. J Biol Chem. 1973 Jun 10;248(11):3762-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1605-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 May;72(5):1960-4 - PubMed
    1. Nature. 1975 Aug 7;256(5517):495-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources