Regulatory T cell-subset imbalance in chronic active hepatitis - PubMed (original) (raw)

• PMID: 6175654
• DOI: 10.1007/BF00916892

Regulatory T cell-subset imbalance in chronic active hepatitis

G Carella et al. J Clin Immunol. 1982 Apr.

Abstract

Three monoclonal anti-T-cell antibodies, specifically directed against total T cells (OKT3), inducer-helper T cells (OKT4) and suppressor/cytotoxic T cells (OKT8), were used in this study to analyze peripheral T-cell subsets in hepatitis B surface antigen (HBsAg)-positive and -negative chronic active hepatitis (CAH) patients. Results showed that a clear-cut difference exists in the distribution of peripheral T cells of these two groups of subjects. HBsAg-positive CAH patients had a numerical predominance of peripheral T lymphocytes expressing the characteristics of cytotoxic/suppressor T cells. In contrast, patients with "autoimmune" HBsAg-negative CAH exhibit a predominance of OKT4 cells, namely, the helper-inducer T-cell subset. In addition, high numbers of circulating double labeled cells (expressing both the OKT4 and the OKT8 xenoantigens) were detected in some of the HBsAg-positive and HBsAg-negative CAH patients studied.

PubMed Disclaimer

Similar articles

• Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection.
  Barnaba V, Musca A, Cordova C, Levrero M, Ruocco G, Albertini-Petroni V, Balsano F. Barnaba V, et al. Clin Exp Immunol. 1983 Aug;53(2):281-8. Clin Exp Immunol. 1983. PMID: 6224609 Free PMC article.
• Peripheral T-cell subsets in chronic type B hepatitis: correlation with biochemical and histological activities and hepatitis B e antigen/antibody status.
  Chu CM, Liaw YF, Yang CY, Sheen IS. Chu CM, et al. Cell Immunol. 1984 Jul;86(2):562-6. doi: 10.1016/0008-8749(84)90414-3. Cell Immunol. 1984. PMID: 6234072
• T-cell subsets in the hyporesponsiveness to hepatitis B surface antigen (HBsAg) and antigen-specific suppressor lymphocytes in chronic hepatitis B virus (HBV) infection.
  Barnaba V, Levrero M, Van Dyke AD, Musca A, Cordova C, Balsano F. Barnaba V, et al. Clin Immunol Immunopathol. 1985 Mar;34(3):284-95. doi: 10.1016/0090-1229(85)90177-1. Clin Immunol Immunopathol. 1985. PMID: 2578908
• Analysis with OKT monoclonal antibodies of T-lymphocyte subsets present in blood and liver of patients with chronic active hepatitis.
  Mariani E, Facchini A, Miglio F, Stefanini GF, Mazzetti M, Leupers T, Gasbarrini G, Labò G, Astaldi A. Mariani E, et al. Liver. 1984 Feb;4(1):22-8. doi: 10.1111/j.1600-0676.1984.tb00903.x. Liver. 1984. PMID: 6230498
• Studies of immune functions of patients with chronic hepatitis.
  Nonomura A, Tanino M, Kurumaya H, Ohta G, Kato Y, Kobayashi K. Nonomura A, et al. Tohoku J Exp Med. 1982 Jun;137(2):163-77. doi: 10.1620/tjem.137.163. Tohoku J Exp Med. 1982. PMID: 6214045 Review.

Cited by

• Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load.
  You J, Zhuang L, Zhang YF, Chen HY, Sriplung H, Geater A, Chongsuvivatwong V, Piratvisuth T, McNeil E, Yu L, Tang BZ, Huang JH. You J, et al. World J Gastroenterol. 2009 Jul 21;15(27):3382-93. doi: 10.3748/wjg.15.3382. World J Gastroenterol. 2009. PMID: 19610139 Free PMC article.
• Flow cytometry CD4+/CD8+ ratio of liver-derived lymphocytes correlates with viral replication in chronic hepatitis B.
  Pham BN, Mosnier JF, Walker F, Njapoum C, Bougy F, Degott C, Erlinger S, Cohen JH, Degos F. Pham BN, et al. Clin Exp Immunol. 1994 Sep;97(3):403-10. doi: 10.1111/j.1365-2249.1994.tb06102.x. Clin Exp Immunol. 1994. PMID: 7915977 Free PMC article.
• Studies of lymphocyte subpopulations in the liver tissue and blood of patients with chronic active hepatitis (CAH).
  Si LS, Whiteside TL, Schade RR, Van Thiel DH. Si LS, et al. J Clin Immunol. 1983 Oct;3(4):408-19. doi: 10.1007/BF00915803. J Clin Immunol. 1983. PMID: 6606644
• Cellular immune responses in the acute exacerbation of hepatitis B e antigen-positive type B chronic hepatitis.
  Hyodo I, Yamada G, Nagashima H. Hyodo I, et al. Gastroenterol Jpn. 1985 Aug;20(4):315-23. doi: 10.1007/BF02774741. Gastroenterol Jpn. 1985. PMID: 3876959
• Functional characterization of peripheral blood lymphocytes in chronic HBsAg carriers.
  Alexander GJ, Mondelli M, Naumov NV, Nouriaria KT, Vergani D, Lowe D, Eddleston AL, Williams R. Alexander GJ, et al. Clin Exp Immunol. 1986 Mar;63(3):498-507. Clin Exp Immunol. 1986. PMID: 2940037 Free PMC article.

References

1. 1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1549-53 - PubMed
2. 1. Clin Exp Immunol. 1981 Jul;45(1):1-8 - PubMed
3. 1. J Immunol. 1980 Mar;124(3):1301-7 - PubMed
4. 1. Nature. 1980 Jul 31;286(5772):533-5 - PubMed
5. 1. J Immunol. 1979 Dec;123(6):2894-6 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Medical

  • MedlinePlus Health Information