Brain transmitter precursors and metabolites in diabetic ketoacidosis - PubMed (original) (raw)
Brain transmitter precursors and metabolites in diabetic ketoacidosis
G Curzon et al. J Neurol Neurosurg Psychiatry. 1982 Jun.
Abstract
Patients studied during recovery from an episode of ketoacidotic diabetes had raised blood glucose, plasma free fatty acid and plasma free tryptophan concentrations. Plasma total tryptophan was decreased. Well controlled diabetics showed normal values. The ketoacidotic patients had increased lumbar CSF tryptophan and 5-hydroxyindoleacetic acid concentrations. Plasma tyrosine and CSF tyrosine and homovanillic acid concentrations were normal in both diabetic groups. The results are discussed in relation to somewhat similar findings in uraemic and hepatic encephalopathy and to changes in rats with streptozotocin diabetes.
Similar articles
- Cerebral transmitter precursors and metabolites in advanced renal disease.
Sullivan PA, Murnaghan D, Callaghan N, Kantamaneni BD, Curzon G. Sullivan PA, et al. J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):581-8. doi: 10.1136/jnnp.41.7.581. J Neurol Neurosurg Psychiatry. 1978. PMID: 29080 Free PMC article. - Dopamine and serotonin metabolism in hepatic encephalopathy.
Knell AJ, Davidson AR, Williams R, Kantamaneni BD, Curzon G. Knell AJ, et al. Br Med J. 1974 Mar 23;1(5907):549-51. doi: 10.1136/bmj.1.5907.549. Br Med J. 1974. PMID: 4817189 Free PMC article. - Effect of dialysis on plasma and CSF tryptophan and CSF 5-hydroxyindoleacetic acid in advanced renal disease.
Sullivan PA, Murnaghan D, Callaghan N, Kantamaneni BD, Curzon G. Sullivan PA, et al. J Neurol Neurosurg Psychiatry. 1980 Aug;43(8):739-43. doi: 10.1136/jnnp.43.8.739. J Neurol Neurosurg Psychiatry. 1980. PMID: 6159456 Free PMC article. - Monoamine metabolites in human cerebrospinal fluid: indicators of neuronal activity?
Scheinin M. Scheinin M. Med Biol. 1985;63(1):1-17. Med Biol. 1985. PMID: 2582215 Review. - Monitoring in vivo of transmitter metabolism by electrochemical methods.
Hutson PH, Curzon G. Hutson PH, et al. Biochem J. 1983 Apr 1;211(1):1-12. doi: 10.1042/bj2110001. Biochem J. 1983. PMID: 6191755 Free PMC article. Review. No abstract available.
Cited by
- Serotonin (5-HT) and the rat's eye. Some pilot studies.
Boerrigter RM, Siertsema JV, Kema IP. Boerrigter RM, et al. Doc Ophthalmol. 1992;82(1-2):141-50. doi: 10.1007/BF00157004. Doc Ophthalmol. 1992. PMID: 1305018
References
- N Engl J Med. 1967 Mar 23;276(12):665-9 - PubMed
- J Pharmacol Exp Ther. 1980 Feb;212(2):269-73 - PubMed
- Br J Clin Pharmacol. 1975 Apr;2(2):165-72 - PubMed
- Anal Biochem. 1977 Nov;83(1):130-42 - PubMed
- Br Med J. 1961 Jan 28;1(5221):247-50 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources