Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy - PubMed (original) (raw)
- PMID: 6198458
- DOI: 10.1007/BF01252805
Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy
S N Young et al. J Neural Transm. 1983.
Abstract
Kynurenine, tryptophan and 5-hydroxyindoleacetic acid were measured in human lumbar and cisternal cerebrospinal fluid (CSF) taken during pneumoencephalography. The results do not support the hypothesis that any substantial part of the CSF kynurenine is of central origin. However, the results suggest that CSF kynurenine is reduced in some epileptic subjects and this seems to be due to the disease rather than anticonvulsants. This finding is of interest in view of the reported convulsant effect of kynurenine in experimental animals.
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References
- Br J Pharmacol. 1979 Jul;66(3):483P-484P - PubMed
- Scand J Clin Lab Invest Suppl. 1974;136:1-186 - PubMed
- J Neurochem. 1975 Mar;24(3):587-9 - PubMed
- J Neurol Neurosurg Psychiatry. 1975 Apr;38(4):322-30 - PubMed
- Brain Res. 1974 Oct 11;79(1):1-8 - PubMed
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