Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists - PubMed (original) (raw)
. 1984 Oct;311(5986):538-44.
doi: 10.1038/311538a0.
- PMID: 6207437
- DOI: 10.1038/311538a0
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
P Hess et al. Nature. 1984 Oct.
Abstract
Single cardiac transmembranous Ca channels have three modes of gating behaviour in the absence of drugs, expressed as current records with brief openings (mode 1), with no openings because of channel unavailability (mode 0 or null mode) and with long-lasting openings and very brief closings that appear only rarely (mode 2). The dihydropyridine Ca agonist Bay K 8644 enhances Ca channel current by promoting mode 2, while the Ca antagonists nitrendipine and nimodipine inhibit the current by favouring mode 0.
Similar articles
- The agonist effect of dihydropyridines on Ca channels.
Brown AM, Kunze DL, Yatani A. Brown AM, et al. Nature. 1984 Oct 11-17;311(5986):570-2. doi: 10.1038/311570a0. Nature. 1984. PMID: 6207438 - Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644.
Nowycky MC, Fox AP, Tsien RW. Nowycky MC, et al. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2178-82. doi: 10.1073/pnas.82.7.2178. Proc Natl Acad Sci U S A. 1985. PMID: 2580308 Free PMC article. - Dihydropyridine calcium agonist and antagonist effects on aldosterone secretion.
Kojima K, Kojima I, Rasmussen H. Kojima K, et al. Am J Physiol. 1984 Nov;247(5 Pt 1):E645-50. doi: 10.1152/ajpendo.1984.247.5.E645. Am J Physiol. 1984. PMID: 6208793 - Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists.
Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC. Tsien RW, et al. J Mol Cell Cardiol. 1986 Jul;18(7):691-710. doi: 10.1016/s0022-2828(86)80941-5. J Mol Cell Cardiol. 1986. PMID: 2427730 Review. - Activators and inactivators of Ca++ channels: new perspectives.
Spedding M. Spedding M. J Pharmacol. 1985 Oct-Dec;16(4):319-43. J Pharmacol. 1985. PMID: 2419702 Review.
Cited by
- Ca2+ regulation of glutamate release from inner hair cells of hearing mice.
Jaime Tobón LM, Moser T. Jaime Tobón LM, et al. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. doi: 10.1073/pnas.2311539120. Epub 2023 Nov 29. Proc Natl Acad Sci U S A. 2023. PMID: 38019860 Free PMC article. - Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels.
Tikhonov DB, Zhorov BS. Tikhonov DB, et al. J Gen Physiol. 2023 Nov 6;155(11):e202313418. doi: 10.1085/jgp.202313418. Epub 2023 Sep 20. J Gen Physiol. 2023. PMID: 37728574 Free PMC article. - Ca2+ spark latency and control of intrinsic Ca2+ release dyssynchrony in rat cardiac ventricular muscle cells.
Kong CHT, Cannell MB. Kong CHT, et al. J Mol Cell Cardiol. 2023 Sep;182:44-53. doi: 10.1016/j.yjmcc.2023.07.005. Epub 2023 Jul 9. J Mol Cell Cardiol. 2023. PMID: 37433391 Free PMC article. - Smooth Muscle Cells of Dystrophic (mdx) Mice Are More Susceptible to Hypoxia; The Protective Effect of Reducing Ca2+ Influx.
Uryash A, Mijares A, Estève E, Adams JA, Lopez JR. Uryash A, et al. Biomedicines. 2023 Feb 19;11(2):623. doi: 10.3390/biomedicines11020623. Biomedicines. 2023. PMID: 36831159 Free PMC article. - Sympathetic Nervous System Regulation of Cardiac Calcium Channels.
Del Rivero Morfin PJ, Marx SO, Ben-Johny M. Del Rivero Morfin PJ, et al. Handb Exp Pharmacol. 2023;279:59-82. doi: 10.1007/164_2022_632. Handb Exp Pharmacol. 2023. PMID: 36592229
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources