Active chromatin - PubMed (original) (raw)
Review
. 1982 May 27;297(5864):289-95.
doi: 10.1038/297289a0.
- PMID: 6210847
- DOI: 10.1038/297289a0
Review
Active chromatin
S Weisbrod. Nature. 1982.
Abstract
Active genes are packaged into an altered nucleosome structure forming a chromosomal domain defined by increased sensitivity to nucleases. This structure, reflecting a potential for transcription, contains sites hypersensitive to nuclease digestion adjacent to the coding regions and may also be distinguished by specific non-histone proteins, variant or modified histones or modified DNA. Its formation, by unfolding of a tightly packed chromatin fibre by factors which might affect DNA supercoiling, may be the first step in gene activation.
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