The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence - PubMed (original) (raw)
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence
S L McKnight et al. Cell. 1984 May.
Abstract
The two distal transcription signals of the herpesvirus tk gene share a common hexanucleotide sequence and function in a mutually dependent manner. We examined their roles by introducing corresponding base mutations into each hexanucleotide. The effects of mutations in the hexanucleotide of the first distal signal match the pattern of effects of the corresponding mutations in the second distal signal. These concordant patterns suggest that the hexanucleotide repeats are functionally analogous. There is one difference between the two distal signals. Disruption of the second distal signal concomitantly inactivates the first distal signal; disruption of the first distal signal leads to only partial inactivation of the second distal signal. When the positions of the two distal signals are switched, the partial dependence of the second distal signal is alleviated. We suggest a model for positive transcriptional control analogous to activation of the cl maintenance promoter of bacteriophage lambda by repressor.
Similar articles
- "Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.
ElKareh A, Murphy AJ, Fichter T, Efstratiadis A, Silverstein S. ElKareh A, et al. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1002-6. doi: 10.1073/pnas.82.4.1002. Proc Natl Acad Sci U S A. 1985. PMID: 2983322 Free PMC article. - The nucleotide sequence of the equine herpesvirus 4 thymidine kinase gene.
Nicolson L, Cullinane AA, Onions DE. Nicolson L, et al. J Gen Virol. 1990 Aug;71 ( Pt 8):1801-5. doi: 10.1099/0022-1317-71-8-1801. J Gen Virol. 1990. PMID: 2391500 - Characterization of eukaryotic transcriptional control signals by assay of herpes simplex virus type 1 thymidine kinase.
Lang JC, Wilkie NM, Spandidos DA. Lang JC, et al. J Gen Virol. 1983 Dec;64 ( Pt 12):2679-96. doi: 10.1099/0022-1317-64-12-2679. J Gen Virol. 1983. PMID: 6319553 - The structure and function of a eukaryotic promoter.
McKnight SL, Chao M, Sweet RW, Silverstein S, Axel R. McKnight SL, et al. Princess Takamatsu Symp. 1982;12:73-85. Princess Takamatsu Symp. 1982. PMID: 6300029 - Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.
Topalis D, Gillemot S, Snoeck R, Andrei G. Topalis D, et al. Drug Resist Updat. 2018 Mar;37:1-16. doi: 10.1016/j.drup.2018.01.003. Epub 2018 Jan 31. Drug Resist Updat. 2018. PMID: 29548479 Review.
Cited by
- High-Level rAAV Vector Production by rAdV-Mediated Amplification of Small Amounts of Input Vector.
Weger S. Weger S. Viruses. 2022 Dec 24;15(1):64. doi: 10.3390/v15010064. Viruses. 2022. PMID: 36680104 Free PMC article. - Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets.
Xie Y, Wu L, Wang M, Cheng A, Yang Q, Wu Y, Jia R, Zhu D, Zhao X, Chen S, Liu M, Zhang S, Wang Y, Xu Z, Chen Z, Zhu L, Luo Q, Liu Y, Yu Y, Zhang L, Chen X. Xie Y, et al. Front Microbiol. 2019 May 8;10:941. doi: 10.3389/fmicb.2019.00941. eCollection 2019. Front Microbiol. 2019. PMID: 31134006 Free PMC article. Review. - Comparative genetic analysis of the 45S rDNA intergenic spacers from three Saccharum species.
Huang Y, Yu F, Li X, Luo L, Wu J, Yang Y, Deng Z, Chen R, Zhang M. Huang Y, et al. PLoS One. 2017 Aug 17;12(8):e0183447. doi: 10.1371/journal.pone.0183447. eCollection 2017. PLoS One. 2017. PMID: 28817651 Free PMC article. - CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes.
Zhao Z, Tang KW, Muylaert I, Samuelsson T, Elias P. Zhao Z, et al. J Biol Chem. 2017 Sep 15;292(37):15489-15500. doi: 10.1074/jbc.M117.806000. Epub 2017 Jul 25. J Biol Chem. 2017. PMID: 28743741 Free PMC article. - Structure and organization of two divergent α-amylase genes from barley.
Knox CA, Sonthayanon B, Chandra GR, Muthukrishnan S. Knox CA, et al. Plant Mol Biol. 1987 Jan;9(1):3-17. doi: 10.1007/BF00017982. Plant Mol Biol. 1987. PMID: 24276793
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases