Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells - PubMed (original) (raw)
Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells
A Rodriguez-Pena et al. Biochem Biophys Res Commun. 1984.
Abstract
Treatment of intact 3T3 cells with biologically active phorbol esters causes a progressive decline in the total activity of Ca2+-sensitive, phospholipid-dependent protein kinase (protein kinase C) measured in cell-free, detergent-solubilized, extracts. The effect is dose-dependent and reversible; protein kinase C activity reappears when the phorbol esters are removed from the medium.
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