Histone 2B can be modified by the attachment of ubiquitin - PubMed (original) (raw)

Comparative Study

Histone 2B can be modified by the attachment of ubiquitin

M H West et al. Nucleic Acids Res. 1980.

Free PMC article

Abstract

Histone 2B in mouse and man can be modified by the post-translational addition of ubiquitin. In mouse L1210 cells, both H2B variants are modified, however only to the extent of 1-1.5% compared with about 11% of H2A. Analysis of cyanogen bromide peptides shows that ubiquitin is attached to the C-terminal part of the histone.

PubMed Disclaimer

Similar articles

• Histone 2A, a heteromorphous family of eight protein species.
  West MH, Bonner WM. West MH, et al. Biochemistry. 1980 Jul 8;19(14):3238-45. doi: 10.1021/bi00555a022. Biochemistry. 1980. PMID: 7407044
• Structure of polyubiquitinated histone H2A.
  Nickel BE, Davie JR. Nickel BE, et al. Biochemistry. 1989 Feb 7;28(3):964-8. doi: 10.1021/bi00429a007. Biochemistry. 1989. PMID: 2540826
• Metabolism of ubiquitinated histones.
  Wu RS, Kohn KW, Bonner WM. Wu RS, et al. J Biol Chem. 1981 Jun 10;256(11):5916-20. J Biol Chem. 1981. PMID: 6263895
• H2B ubiquitylation: the end is in sight.
  Osley MA. Osley MA. Biochim Biophys Acta. 2004 Mar 15;1677(1-3):74-8. doi: 10.1016/j.bbaexp.2003.10.013. Biochim Biophys Acta. 2004. PMID: 15020048 Review.
• The role of histone H2A and H2B post-translational modifications in transcription: a genomic perspective.
  Wyrick JJ, Parra MA. Wyrick JJ, et al. Biochim Biophys Acta. 2009 Jan;1789(1):37-44. doi: 10.1016/j.bbagrm.2008.07.001. Epub 2008 Jul 14. Biochim Biophys Acta. 2009. PMID: 18675384 Review.

Cited by

• The spread of chemical biology into chromatin.
  Hegazi E, Muir TW. Hegazi E, et al. J Biol Chem. 2024 Sep 12;300(11):107776. doi: 10.1016/j.jbc.2024.107776. Online ahead of print. J Biol Chem. 2024. PMID: 39276931 Free PMC article. Review.
• Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure.
  Fetian T, Grover A, Arndt KM. Fetian T, et al. Biochim Biophys Acta Gene Regul Mech. 2024 Jun;1867(2):195018. doi: 10.1016/j.bbagrm.2024.195018. Epub 2024 Feb 6. Biochim Biophys Acta Gene Regul Mech. 2024. PMID: 38331024 Review.
• Collaborators or competitors: the communication between RNA polymerase II and the nucleosome during eukaryotic transcription.
  Hardtke HA, Zhang YJ. Hardtke HA, et al. Crit Rev Biochem Mol Biol. 2024 Feb-Apr;59(1-2):1-19. doi: 10.1080/10409238.2024.2306365. Epub 2024 Jan 30. Crit Rev Biochem Mol Biol. 2024. PMID: 38288999 Review.
• Global histone H2B degradation regulates insulin/IGF signaling-mediated nutrient stress.
  Zhu Z, Li D, Jia Z, Zhang W, Chen Y, Zhao R, Zhang YP, Zhang WH, Deng H, Li Y, Li W, Guang S, Ou G. Zhu Z, et al. EMBO J. 2023 Oct 4;42(19):e113328. doi: 10.15252/embj.2022113328. Epub 2023 Aug 29. EMBO J. 2023. PMID: 37641865 Free PMC article.
• H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
  Ferrari AJ, Rawat P, Rendulich HS, Annapragada AV, Kinose Y, Zhang X, Devins K, Budina A, Scharpf RB, Mitchell MA, Tanyi JL, Morgan MA, Schwartz LE, Soong TR, Velculescu VE, Drapkin R. Ferrari AJ, et al. JCI Insight. 2023 Jun 22;8(12):e164995. doi: 10.1172/jci.insight.164995. JCI Insight. 2023. PMID: 37345659 Free PMC article.

References

1. 1. Eur J Biochem. 1974 Jul 1;46(1):83-8 - PubMed
2. 1. Nature. 1977 Mar 17;266(5599):273-5 - PubMed
3. 1. Methods Cell Biol. 1978;17:223-33 - PubMed
4. 1. Biochemistry. 1980 Jul 8;19(14):3238-45 - PubMed
5. 1. Eur J Biochem. 1980 Aug;109(1):17-23 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database