Linkage of the four gamma subclass heavy chain genes - PubMed (original) (raw)
Linkage of the four gamma subclass heavy chain genes
W Roeder et al. Proc Natl Acad Sci U S A. 1981 Jan.
Abstract
The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and another of 15 kb, that surround the C gamma 2b and C gamma 2a genes, respectively, show considerable homology and implicate a tandem duplication mechanism in the evolution of this gene cluster.
Similar articles
- Cloned embryonic DNA sequences flanking the mouse immunoglobulin C gamma 3 and C gamma 1 genes.
Adams JM, Webb E, Gerondakis S, Cory S. Adams JM, et al. Nucleic Acids Res. 1980 Dec 20;8(24):6019-32. doi: 10.1093/nar/8.24.6019. Nucleic Acids Res. 1980. PMID: 6258159 Free PMC article. - Structure of immunoglobulin gamma 2b heavy chain gene cloned from mouse embryo gene library.
Zakut R, Givol D, Mory YY. Zakut R, et al. Nucleic Acids Res. 1980 Feb 11;8(3):453-66. doi: 10.1093/nar/8.3.453. Nucleic Acids Res. 1980. PMID: 6255443 Free PMC article. - Nucleotide sequence and properties of the murine gamma 3 immunoglobulin heavy chain gene switch region: implications for successive C gamma gene switching.
Stanton LW, Marcu KB. Stanton LW, et al. Nucleic Acids Res. 1982 Oct 11;10(19):5993-6006. doi: 10.1093/nar/10.19.5993. Nucleic Acids Res. 1982. PMID: 6292864 Free PMC article. - Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expression.
Tilley SA, Birshtein BK. Tilley SA, et al. J Exp Med. 1985 Aug 1;162(2):675-94. doi: 10.1084/jem.162.2.675. J Exp Med. 1985. PMID: 3926937 Free PMC article. Review. - Lessons learned, promises kept: a biologist's eye view of the Genome Project.
Tilghman SM. Tilghman SM. Genome Res. 1996 Sep;6(9):773-80. doi: 10.1101/gr.6.9.773. Genome Res. 1996. PMID: 8889546 Review. No abstract available.
Cited by
- A mouse/human chimeric anti-(ganglioside GD3) antibody with enhanced antitumor activities.
Shitara K, Kuwana Y, Nakamura K, Tokutake Y, Ohta S, Miyaji H, Hasegawa M, Hanai N. Shitara K, et al. Cancer Immunol Immunother. 1993 Jun;36(6):373-80. doi: 10.1007/BF01742253. Cancer Immunol Immunother. 1993. PMID: 8500110 Free PMC article. - Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes.
Nishida Y, Miki T, Hisajima H, Honjo T. Nishida Y, et al. Proc Natl Acad Sci U S A. 1982 Jun;79(12):3833-7. doi: 10.1073/pnas.79.12.3833. Proc Natl Acad Sci U S A. 1982. PMID: 6808515 Free PMC article. - Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.
Ellison J, Hood L. Ellison J, et al. Proc Natl Acad Sci U S A. 1982 Mar;79(6):1984-8. doi: 10.1073/pnas.79.6.1984. Proc Natl Acad Sci U S A. 1982. PMID: 6804948 Free PMC article. - Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.
Kurosawa Y, Tonegawa S. Kurosawa Y, et al. J Exp Med. 1982 Jan 1;155(1):201-18. doi: 10.1084/jem.155.1.201. J Exp Med. 1982. PMID: 6798155 Free PMC article.
References
- Ann N Y Acad Sci. 1971 Dec 31;190:420-31 - PubMed
- Nucleic Acids Res. 1980 Jul 25;8(14):3143-55 - PubMed
- Proc Natl Acad Sci U S A. 1976 Oct;73(10):3628-32 - PubMed
- Science. 1977 Apr 8;196(4286):161-9 - PubMed
- Science. 1977 Apr 8;196(4286):180-2 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases