Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids - PubMed (original) (raw)
. 1981 Nov 19;294(5838):228-32.
doi: 10.1038/294228a0.
- PMID: 6272123
- DOI: 10.1038/294228a0
Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids
F Lee et al. Nature. 1981.
Abstract
Fusions between the mouse mammary tumour virus long terminal repeat and a mouse dihydrofolate reductase cDNA have been constructed in a SV40 vector. When these plasmids are transferred into recipient cells, the production of dihydrofolate reductase is regulated by glucocorticoid hormones. These results define a hormonally responsive region of the viral genome.
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