Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients - PubMed (original) (raw)

Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients

G V Quinnan Jr et al. N Engl J Med. 1982.

Abstract

We studied 58 recipients of bone-marrow transplants to evaluate immune responses to cytomegalovirus infection. Such infection developed in 43 patients; it was fatal in 12, nonfatal in 23, and present at death from other causes in eight. All patients had low or absent cytomegalovirus-specific cytotoxic lymphocyte activity before the onset of infection. Cytomegalovirus-specific cytotoxic responses developed in all survivors, whereas only two patients with fatal infection had even low-level cytomegalovirus-specific cytotoxic responses. Natural and antibody-dependent killer-cell activities were depressed both before and during infection in patients with fatal infections, but not in those who survived. The outcome of the infection did not correlate with the nature of the underlying disease, the type of transplant received, the pretransplantation cytomegalovirus-antibody status, or lymphocyte-proliferation responses to cytomegalovirus antigens or concanavalin A. The correlation between effective virus-specific cytotoxic response and recovery from infection indicates that these effector cells probably mediate recovery from cytomegalovirus infection.

PubMed Disclaimer

Cited by

Efficacy and Safety of a Preemptive Antiviral Therapy Strategy Based on Combined Virological and Immunological Monitoring for Active Cytomegalovirus Infection in Allogeneic Stem Cell Transplant Recipients.
Navarro D, Amat P, de la Cámara R, López J, Vázquez L, Serrano D, Nieto J, Rovira M, Piñana JL, Giménez E, Solano C. Navarro D, et al. Open Forum Infect Dis. 2016 May 18;3(2):ofw107. doi: 10.1093/ofid/ofw107. eCollection 2016 Apr. Open Forum Infect Dis. 2016. PMID: 27419179 Free PMC article.
Lymphocyte proliferative responses to human immunodeficiency virus antigens in vitro.
Krowka JF, Stites DP, Jain S, Steimer KS, George-Nascimento C, Gyenes A, Barr PJ, Hollander H, Moss AR, Homsy JM, et al. Krowka JF, et al. J Clin Invest. 1989 Apr;83(4):1198-203. doi: 10.1172/JCI114001. J Clin Invest. 1989. PMID: 2703528 Free PMC article.
A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6.
Littaua RA, Oldstone MB, Takeda A, Ennis FA. Littaua RA, et al. J Virol. 1992 Jan;66(1):608-11. doi: 10.1128/JVI.66.1.608-611.1992. J Virol. 1992. PMID: 1370094 Free PMC article.
Lung diseases after bone marrow transplantation. Results of a clinical, radiological, histological, immunological and lung function study.
Link H, Reinhard U, Walter E, Wernet P, Schneider EM, Fischbach H, Blaurock M, Wilms K, Niethammer D, Ostendorf P. Link H, et al. Klin Wochenschr. 1986 Jul 1;64(13):595-614. doi: 10.1007/BF01735262. Klin Wochenschr. 1986. PMID: 3528653 Free PMC article.
Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89.
Del Val M, Volkmer H, Rothbard JB, Jonjić S, Messerle M, Schickedanz J, Reddehase MJ, Koszinowski UH. Del Val M, et al. J Virol. 1988 Nov;62(11):3965-72. doi: 10.1128/JVI.62.11.3965-3972.1988. J Virol. 1988. PMID: 2459408 Free PMC article.

Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients - PubMed (original) (raw)