Gap junctional conductance: comparison of sensitivities to H and Ca ions - PubMed (original) (raw)

Gap junctional conductance: comparison of sensitivities to H and Ca ions

D C Spray et al. Proc Natl Acad Sci U S A. 1982 Jan.

Abstract

One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.

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