Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas - PubMed (original) (raw)

Comparative Study

. 1983 Jun;303(5916):401-6.

doi: 10.1038/303401a0.

• PMID: 6304522
• DOI: 10.1038/303401a0

Comparative Study

Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

L W Stanton et al. Nature. 1983 Jun.

Abstract

Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the first exon or intron. In the plasmacytoma truncated c-myc RNAs initiate from newly exposed promoter sites. Nevertheless, the myc polypeptide produced in the plasmacytoma is probably the same as that from the intact c-myc gene because the exon lost by breakage and translocation is non-coding. The second and third exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29.

PubMed Disclaimer

Similar articles

• Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.
  Adams JM, Gerondakis S, Webb E, Corcoran LM, Cory S. Adams JM, et al. Proc Natl Acad Sci U S A. 1983 Apr;80(7):1982-6. doi: 10.1073/pnas.80.7.1982. Proc Natl Acad Sci U S A. 1983. PMID: 6572957 Free PMC article.
• Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia.
  Marcu KB, Harris LJ, Stanton LW, Erikson J, Watt R, Croce CM. Marcu KB, et al. Proc Natl Acad Sci U S A. 1983 Jan;80(2):519-23. doi: 10.1073/pnas.80.2.519. Proc Natl Acad Sci U S A. 1983. PMID: 6188153 Free PMC article.
• Constitutive activation of oncogenes by chromosomal translocations in B-cell derived tumors.
  Klein G. Klein G. AIDS Res. 1986 Dec;2 Suppl 1:S167-76. AIDS Res. 1986. PMID: 3030345 Review.
• Structural and functional chimerism results from chromosomal translocation in lymphoid tumors.
  Rabbitts TH, Boehm T. Rabbitts TH, et al. Adv Immunol. 1991;50:119-46. doi: 10.1016/s0065-2776(08)60824-x. Adv Immunol. 1991. PMID: 1950795 Review. No abstract available.

Cited by

• Target sequences for cis-acting regulation within the dual promoter of the human c-myc gene.
  Lipp M, Schilling R, Wiest S, Laux G, Bornkamm GW. Lipp M, et al. Mol Cell Biol. 1987 Apr;7(4):1393-400. doi: 10.1128/mcb.7.4.1393-1400.1987. Mol Cell Biol. 1987. PMID: 3037316 Free PMC article.
• Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162.
  Tian SS, Faust C. Tian SS, et al. Mol Cell Biol. 1987 Jul;7(7):2614-9. doi: 10.1128/mcb.7.7.2614-2619.1987. Mol Cell Biol. 1987. PMID: 3112560 Free PMC article.
• Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.
  Rollins BJ, Morrison ED, Stiles CD. Rollins BJ, et al. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3738-42. doi: 10.1073/pnas.85.11.3738. Proc Natl Acad Sci U S A. 1988. PMID: 3287374 Free PMC article.
• Expression of a growth arrest specific gene (gas-1) in transformed cells.
  Cairo G, Ferrero M, Biondi G, Colombo MP. Cairo G, et al. Br J Cancer. 1992 Jul;66(1):27-31. doi: 10.1038/bjc.1992.211. Br J Cancer. 1992. PMID: 1379061 Free PMC article.
• Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.
  Nishikura K, Murray JM. Nishikura K, et al. Mol Cell Biol. 1987 Feb;7(2):639-49. doi: 10.1128/mcb.7.2.639-649.1987. Mol Cell Biol. 1987. PMID: 3547078 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)