Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus - PubMed (original) (raw)

Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus

Y K Fung et al. Cell. 1983 Jun.

Abstract

Avian leukosis virus (ALV), a slowly oncogenic retrovirus, induces in chickens a variety of neoplasms, including lymphoid leukosis and erythroblastosis. In lymphoid leukosis, a cellular oncogene, c-myc, is activated by the insertion of ALV LTR. We provide evidence that ALV utilizes a similar mechanism in erythroblastosis induction by activating a different cellular oncogene, c-erbB. We report the isolation, from leukemic erythroblast DNA, of a clone that represents the viral-cell junction fragment and carried the ALV LTR and part of the c-erbB locus. Restriction and sequence analyses reveal that the LTR is located upstream from the erbB coding region and is oriented in the same transcriptional direction; such a structure would be compatible with the promoter-insertion type of activation. Our findings provide a molecular explanation for the multipotency of slowly oncogenic retroviruses.

PubMed Disclaimer

Cited by

Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens.
Mays JK, Black-Pyrkosz A, Mansour T, Schutte BC, Chang S, Dong K, Hunt HD, Fadly AM, Zhang L, Zhang H. Mays JK, et al. J Virol. 2019 Nov 13;93(23):e00861-19. doi: 10.1128/JVI.00861-19. Print 2019 Dec 1. J Virol. 2019. PMID: 31554689 Free PMC article.
MiR-125b Suppression Inhibits Apoptosis and Negatively Regulates Sema4D in Avian Leukosis Virus-Transformed Cells.
Ren C, Xie R, Yao Y, Yu M, Chang F, Xing L, Zhang Y, Liu Y, Wang S, Farooque M, Wang Y, Qi X, Liu C, Zhang Y, Cui H, Li K, Gao L, Pan Q, Nair V, Wang X, Gao Y. Ren C, et al. Viruses. 2019 Aug 7;11(8):728. doi: 10.3390/v11080728. Viruses. 2019. PMID: 31394878 Free PMC article.
HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2.
Pecenka V, Pajer P, Karafiat V, Kasparova P, Dudlova J, Dvorak M. Pecenka V, et al. J Virol. 2017 Sep 27;91(20):e00467-17. doi: 10.1128/JVI.00467-17. Print 2017 Oct 15. J Virol. 2017. PMID: 28768863 Free PMC article.
Avian leukosis virus subgroup J associated with the outbreak of erythroblastosis in chickens in China.
Wang G, Jiang Y, Yu L, Wang Y, Zhao X, Cheng Z. Wang G, et al. Virol J. 2013 Mar 22;10:92. doi: 10.1186/1743-422X-10-92. Virol J. 2013. PMID: 23521848 Free PMC article.
Insertional oncogenesis by non-acute retroviruses: implications for gene therapy.
Fan H, Johnson C. Fan H, et al. Viruses. 2011 Apr;3(4):398-422. doi: 10.3390/v3040398. Epub 2011 Apr 15. Viruses. 2011. PMID: 21994739 Free PMC article. Review.

Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus - PubMed (original) (raw)