Cholesterol feeding increases low density lipoprotein synthesis - PubMed (original) (raw)

Cholesterol feeding increases low density lipoprotein synthesis

C J Packard et al. J Clin Invest. 1983 Jul.

Abstract

This study examines the effects of increased dietary cholesterol (6 eggs/d) on the metabolism of low density lipoproteins in a group of seven healthy volunteers. Egg supplementation raised high density and low density lipoprotein cholesterol levels by 18 and 40%, respectively. The composition of the low density lipoprotein was unaltered and therefore the number of circulating particles must have increased. Kinetic studies indicated that this was due primarily to a 23% rise in the rate of synthesis of the lipoprotein. Catabolism was also affected. The fractional removal rate of native low density lipoprotein fell by 10% (P less than 0.05). However, the clearance of the 1,2 cyclohexanedione-treated lipoprotein remained unchanged (control fractional clearance rate [FCR] = 0.188 pools/d; cholesterol feeding FCR = 0.183 pools/d). Therefore, the reduction in low density lipoprotein catabolism appeared to be due to a fall in receptor activity. Consequently, an increased sterol load (34.2 mumol/kg per d vs. 27.7 mumol/kg per d in the control phase, P less than 0.02) was channelled into the receptor-independent route during egg feeding.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Clin Invest. 1981 Nov;68(5):1197-206 - PubMed
    1. N Engl J Med. 1981 Jan 8;304(2):65-70 - PubMed
    1. J Clin Invest. 1981 Feb;67(2):493-502 - PubMed
    1. Metabolism. 1976 Sep;25(9):995-1006 - PubMed
    1. Am J Clin Nutr. 1981 Jun;34(6):1103-8 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources