The strength-duration relationship for excitation of myelinated nerve: computed dependence on membrane parameters - PubMed (original) (raw)

The strength-duration relationship for excitation of myelinated nerve: computed dependence on membrane parameters

H Bostock. J Physiol. 1983 Aug.

Abstract

Thresholds to applied current pulses have been determined for the myelinated nerve model of Goldman & Albus (1968). Strength-duration curves have been plotted, and compared with three strength-duration equations that have been proposed in the past. The simple, linear relation between stimulus charge and stimulus duration proposed by Weiss (1901) provided the best fit to the computed data. The effects on the strength-duration relationship of changes in twelve parameters of the model were determined and expressed in terms of the strength-duration time constant and rheobasic current. The rheobase depended primarily on conductances, whereas the strength-duration time constant depended on the electrotonic time constant and also on the rate of sodium activation. The model predicts strength-duration curves of the same form, for extracellular or intracellular stimulation where the external resistance is low and uniform. Tripolar stimulation, with anodes over adjacent rather than remote nodes, is predicted to result in much shorter strength-duration time constants, but with a similar sensitivity to nodal membrane parameters. The limitations of strength-duration measurements on myelinated nerves are discussed in the light of these simulations.

PubMed Disclaimer

Similar articles

• The spatial distribution of excitability and membrane current in normal and demyelinated mammalian nerve fibres.
  Bostock H, Sears TA, Sherratt RM. Bostock H, et al. J Physiol. 1983 Aug;341:41-58. doi: 10.1113/jphysiol.1983.sp014791. J Physiol. 1983. PMID: 6312029 Free PMC article.
• Excitability properties of normal and demyelinated human motor nerve axons.
  Stephanova DI, Daskalova M. Stephanova DI, et al. Electromyogr Clin Neurophysiol. 2004 Apr-May;44(3):147-52. Electromyogr Clin Neurophysiol. 2004. PMID: 15125054
• Effects of stochastic sodium channels on extracellular excitation of myelinated nerve fibers.
  Mino H, Grill WM Jr. Mino H, et al. IEEE Trans Biomed Eng. 2002 Jun;49(6):527-32. doi: 10.1109/TBME.2002.1001966. IEEE Trans Biomed Eng. 2002. PMID: 12046697
• Electrophysiology and morphology of myelinated nerve fibers. VII. The myelinated nerve: some unsolved problems.
  Neumcke B. Neumcke B. Experientia. 1983 Sep 15;39(9):976-9. doi: 10.1007/BF01989762. Experientia. 1983. PMID: 6309558 Review. No abstract available.
• Theoretical evaluation of peripheral nerve stimulation during MRI with an implanted spinal fusion stimulator.
  Reilly JP, Diamant AM. Reilly JP, et al. Magn Reson Imaging. 1997;15(10):1145-56. doi: 10.1016/s0730-725x(97)00162-8. Magn Reson Imaging. 1997. PMID: 9408135 Review.

Cited by

• Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro.
  Radman T, Ramos RL, Brumberg JC, Bikson M. Radman T, et al. Brain Stimul. 2009 Oct;2(4):215-28, 228.e1-3. doi: 10.1016/j.brs.2009.03.007. Brain Stimul. 2009. PMID: 20161507 Free PMC article.
• Characterization of the electrical properties of mammalian peripheral nerve laminae.
  Horn MR, Vetter C, Bashirullah R, Carr M, Yoshida K. Horn MR, et al. Artif Organs. 2023 Apr;47(4):705-720. doi: 10.1111/aor.14500. Epub 2023 Jan 31. Artif Organs. 2023. PMID: 36720049 Free PMC article.
• Function and distribution of three types of rectifying channel in rat spinal root myelinated axons.
  Baker M, Bostock H, Grafe P, Martius P. Baker M, et al. J Physiol. 1987 Feb;383:45-67. doi: 10.1113/jphysiol.1987.sp016395. J Physiol. 1987. PMID: 2443652 Free PMC article.
• The spatial distribution of excitability and membrane current in normal and demyelinated mammalian nerve fibres.
  Bostock H, Sears TA, Sherratt RM. Bostock H, et al. J Physiol. 1983 Aug;341:41-58. doi: 10.1113/jphysiol.1983.sp014791. J Physiol. 1983. PMID: 6312029 Free PMC article.
• Effects of axonal ion channel dysfunction on quality of life in type 2 diabetes.
  Kwai NC, Arnold R, Wickremaarachchi C, Lin CS, Poynten AM, Kiernan MC, Krishnan AV. Kwai NC, et al. Diabetes Care. 2013 May;36(5):1272-7. doi: 10.2337/dc12-1310. Epub 2013 Feb 12. Diabetes Care. 2013. PMID: 23404298 Free PMC article.

References

1. 1. J Physiol. 1979 Jul;292:149-66 - PubMed
2. 1. J Physiol. 1963 Nov;169:431-7 - PubMed
3. 1. J Physiol. 1970 Jun;208(2):279-89 - PubMed
4. 1. J Physiol. 1965 Oct;180(4):780-7 - PubMed
5. 1. Biophys J. 1968 May;8(5):596-607 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • PubMed Central
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal