Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activity - PubMed (original) (raw)

Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activity

P Whitaker-Dowling et al. Virology. 1983 Nov.

Abstract

Coinfection with vaccinia virus rescues vesicular stomatitis virus (VSV) from the inhibitory effects of interferon (IFN) in mouse L cells. While vaccinia infection does not significantly affect VSV RNA synthesis, coinfection with vaccinia dramatically increases VSV protein synthesis in IFN-treated cells. Evidence is provided that vaccinia inhibits the activity of the IFN-induced dsRNA-dependent protein kinase.

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