Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas - PubMed (original) (raw)
Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas
J Dudley et al. J Virol. 1984 Jan.
Abstract
Endogenous mouse mammary tumor virus genomes are amplified and located in novel cell DNA sequences in many mouse T-cell lymphomas. Transplanted tumors recovered from the same mouse strain and shown to be of independent origin by chromosomal analysis, by the presence of JH immunoglobulin gene rearrangements, or by the integration patterns of exogenous Moloney MuLV genomes frequently showed similar patterns of novel mouse mammary tumor virus-containing cell DNA fragments. This process of amplification and relocation can occur within a limited number of cell generations and in C57BL/6 mice does not lead to the synthesis of mature virus-encoded proteins. In some instances, amplified mouse mammary tumor virus genomes contained novel restriction cleavage sites in the gag-pol region. The restricted time course of occurrence, lack of synthesis of mature virion proteins, and apparent site specificity indicate that this process of retrovirus amplification differs significantly from virus replication after exogenous infection.
Similar articles
- Molecular events in B lymphocyte differentiation. Inducible expression of the endogenous mouse mammary tumor proviral gene, Mtv-9.
King LB, Lund FE, White DA, Sharma S, Corley RB. King LB, et al. J Immunol. 1990 Apr 15;144(8):3218-27. J Immunol. 1990. PMID: 2157765 - Altered mouse mammary tumor virus transcript synthesis in T-cell lymphoma cells.
Racevskis J. Racevskis J. J Virol. 1990 Sep;64(9):4043-50. doi: 10.1128/JVI.64.9.4043-4050.1990. J Virol. 1990. PMID: 1696633 Free PMC article. - Proteins encoded by mouse mammary tumour virus.
Dickson C, Peters G. Dickson C, et al. Curr Top Microbiol Immunol. 1983;106:1-34. doi: 10.1007/978-3-642-69357-1_1. Curr Top Microbiol Immunol. 1983. PMID: 6196157 Review. No abstract available. - Cellular transforming genes and oncogenesis.
Cooper GM, Lane MA. Cooper GM, et al. Biochim Biophys Acta. 1984;738(1-2):9-20. doi: 10.1016/0304-419x(84)90017-9. Biochim Biophys Acta. 1984. PMID: 6331501 Review. No abstract available.
Cited by
- The Immunological Conundrum of Endogenous Retroelements.
Kassiotis G. Kassiotis G. Annu Rev Immunol. 2023 Apr 26;41:99-125. doi: 10.1146/annurev-immunol-101721-033341. Epub 2023 Jan 11. Annu Rev Immunol. 2023. PMID: 36630597 Free PMC article. Review. - Presence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study.
Parisi F, Lessi F, Menicagli M, Civita P, Liotti R, Millanta F, Freer G, Pistello M, Mazzanti CM, Poli A. Parisi F, et al. Infect Agent Cancer. 2022 Jun 23;17(1):35. doi: 10.1186/s13027-022-00449-9. Infect Agent Cancer. 2022. PMID: 35739602 Free PMC article. Review. - A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus.
Singh GB, Byun H, Ali AF, Medina F, Wylie D, Shivram H, Nash AK, Lozano MM, Dudley JP. Singh GB, et al. mBio. 2019 Aug 13;10(4):e01678-19. doi: 10.1128/mBio.01678-19. mBio. 2019. PMID: 31409681 Free PMC article. - Mouse mammary tumor virus integration site selection in human and mouse genomes.
Faschinger A, Rouault F, Sollner J, Lukas A, Salmons B, Günzburg WH, Indik S. Faschinger A, et al. J Virol. 2008 Feb;82(3):1360-7. doi: 10.1128/JVI.02098-07. Epub 2007 Nov 21. J Virol. 2008. PMID: 18032509 Free PMC article. - Conversion of mouse mammary tumor virus to a lymphomagenic virus.
Bhadra S, Lozano MM, Dudley JP. Bhadra S, et al. J Virol. 2005 Oct;79(19):12592-6. doi: 10.1128/JVI.79.19.12592-12596.2005. J Virol. 2005. PMID: 16160187 Free PMC article.
References
- Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 - PubMed
- Science. 1982 Dec 24;218(4579):1319-21 - PubMed
- Exp Cell Res. 1970 Apr;60(1):61-77 - PubMed
- J Virol. 1974 Nov;14(5):1235-44 - PubMed
- Genetics. 1974 Dec;78(4):1143-56 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases