Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system - PubMed (original) (raw)
Comparative Study
Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system
E Paez et al. Virology. 1984.
Abstract
In this investigation the sensitivity of vaccinia virus to interferon (IFN) has been examined in cultured cells. In a variety of mouse and human cells of different origins vaccinia virus functions (RNA, protein, and virus yields) were found to be relatively resistant to IFN. In these systems, the levels of the IFN-mediated enzyme activities (2-5A synthetase and protein kinase) were severely impaired by the virus. This virus-mediated inhibitory effect developed with time after infection and was dependent on viral protein synthesis. Mixed infections between vaccinia virus and viruses (VSV or polio) which are sensitive to IFN showed that both protein synthesis and virus yields were not inhibited. These findings show that vaccinia virus can overcome the antiviral action of IFN and that viral gene functions appear to be involved in this interference phenomenon.
Similar articles
- Mode of sensitivity and resistance of vaccinia virus replication to interferon.
Esteban M, Benavente J, Paez E. Esteban M, et al. J Gen Virol. 1986 Apr;67 ( Pt 4):801-8. doi: 10.1099/0022-1317-67-4-801. J Gen Virol. 1986. PMID: 3958696 - Nature and mode of action of vaccinia virus products that block activation of the interferon-mediated ppp(A2'p)nA-synthetase.
Paez E, Esteban M. Paez E, et al. Virology. 1984 Apr 15;134(1):29-39. doi: 10.1016/0042-6822(84)90269-1. Virology. 1984. PMID: 6324475 - 2-5A accumulates to high levels in interferon-treated, vaccinia virus-infected cells in the absence of any inhibition of virus replication.
Rice AP, Roberts WK, Kerr IM. Rice AP, et al. J Virol. 1984 Apr;50(1):220-8. doi: 10.1128/JVI.50.1.220-228.1984. J Virol. 1984. PMID: 6422053 Free PMC article. - [Alpha interferon, antiviral proteins and their value in clinical medicine].
Chieux V, Hober D, Chehadeh W, Wattré P. Chieux V, et al. Ann Biol Clin (Paris). 1999 Nov-Dec;57(6):659-66. Ann Biol Clin (Paris). 1999. PMID: 10572214 Review. French. - Viruses as model systems in cell biology.
Compans RW, Roberts PC. Compans RW, et al. Methods Cell Biol. 1994;43 Pt A:3-42. doi: 10.1016/s0091-679x(08)60596-8. Methods Cell Biol. 1994. PMID: 7823868 Free PMC article. Review.
Cited by
- Poxvirus pathogenesis.
Buller RM, Palumbo GJ. Buller RM, et al. Microbiol Rev. 1991 Mar;55(1):80-122. doi: 10.1128/mr.55.1.80-122.1991. Microbiol Rev. 1991. PMID: 1851533 Free PMC article. Review. - Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA.
SenGupta DN, Silverman RH. SenGupta DN, et al. Nucleic Acids Res. 1989 Feb 11;17(3):969-78. doi: 10.1093/nar/17.3.969. Nucleic Acids Res. 1989. PMID: 2922280 Free PMC article. - Diverse functions of RNase L and implications in pathology.
Bisbal C, Silverman RH. Bisbal C, et al. Biochimie. 2007 Jun-Jul;89(6-7):789-98. doi: 10.1016/j.biochi.2007.02.006. Epub 2007 Feb 20. Biochimie. 2007. PMID: 17400356 Free PMC article. Review. - Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action.
García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M. García MA, et al. Microbiol Mol Biol Rev. 2006 Dec;70(4):1032-60. doi: 10.1128/MMBR.00027-06. Microbiol Mol Biol Rev. 2006. PMID: 17158706 Free PMC article. Review. - Functional organization of variola major and vaccinia virus genomes.
Shchelkunov SN. Shchelkunov SN. Virus Genes. 1995;10(1):53-71. doi: 10.1007/BF01724297. Virus Genes. 1995. PMID: 7483290 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources