Induction of c-fos gene and protein by growth factors precedes activation of c-myc - PubMed (original) (raw)
- PMID: 6334806
- DOI: 10.1038/312716a0
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
R Müller et al. Nature. 1984.
Abstract
Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This suggests that c-fos induction is a primary event and the earliest known effect on gene expression by growth factors.
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