Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level - PubMed (original) (raw)
Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level
T Leff et al. Proc Natl Acad Sci U S A. 1984 Jul.
Abstract
Recombinant plasmids containing mutant or wild-type adenovirus serotype 2 EIa genes that produce the 12S mRNA alone, the 13S mRNA alone, or both mRNAs were cotransfected into HeLa cells with plasmids containing the viral EIIa or EIII transcription units. The amount of RNA produced from the EIIa and EIII promoters was increased by the products of both the 13S and the 12S RNAs. By measuring the level of specific transcription in nuclei isolated from transfected cells we directly demonstrate that the increased amount of EIIa RNA is due to stimulation of the rate of transcription.
Similar articles
- Sequence-specific trans-activation of the adenovirus EIIa early promoter by the viral EIV transcription unit.
Goding C, Jalinot P, Zajchowski D, Boeuf H, Kédinger C. Goding C, et al. EMBO J. 1985 Jun;4(6):1523-8. doi: 10.1002/j.1460-2075.1985.tb03812.x. EMBO J. 1985. PMID: 4029123 Free PMC article. - EIa-mediated stimulation of the adenovirus EIII promoter involves an enhancer element within the nearby EIIa promoter.
Zajchowski DA, Jalinot P, Kedinger C. Zajchowski DA, et al. J Virol. 1988 May;62(5):1762-7. doi: 10.1128/JVI.62.5.1762-1767.1988. J Virol. 1988. PMID: 2965764 Free PMC article. - Sequence-specific activation of transcription by adenovirus EIa products is observed in HeLa cells but not in 293 cells.
Leff T, Chambon P. Leff T, et al. Mol Cell Biol. 1986 Jan;6(1):201-8. doi: 10.1128/mcb.6.1.201-208.1986. Mol Cell Biol. 1986. PMID: 2946930 Free PMC article. - Regulation of adenovirus gene expression.
Persson H, Philipson L. Persson H, et al. Curr Top Microbiol Immunol. 1982;97:157-203. doi: 10.1007/978-3-642-68318-3_4. Curr Top Microbiol Immunol. 1982. PMID: 7035073 Review. No abstract available. - Post-transcriptional control of adenovirus gene expression.
Imperiale MJ, Akusjnärvi G, Leppard KN. Imperiale MJ, et al. Curr Top Microbiol Immunol. 1995;199 ( Pt 2):139-71. doi: 10.1007/978-3-642-79499-5_6. Curr Top Microbiol Immunol. 1995. PMID: 7555066 Review. No abstract available.
Cited by
- Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A.
Johnson JS, Osheim YN, Xue Y, Emanuel MR, Lewis PW, Bankovich A, Beyer AL, Engel DA. Johnson JS, et al. J Virol. 2004 Jun;78(12):6459-68. doi: 10.1128/JVI.78.12.6459-6468.2004. J Virol. 2004. PMID: 15163739 Free PMC article. - Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein.
Lee BH, Mathews MB. Lee BH, et al. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4481-6. doi: 10.1073/pnas.94.9.4481. Proc Natl Acad Sci U S A. 1997. PMID: 9114015 Free PMC article. - mRNA export correlates with activation of transcription in human subgroup C adenovirus-infected cells.
Yang UC, Huang W, Flint SJ. Yang UC, et al. J Virol. 1996 Jun;70(6):4071-80. doi: 10.1128/JVI.70.6.4071-4080.1996. J Virol. 1996. PMID: 8648745 Free PMC article. - Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a.
Chatton B, Bocco JL, Gaire M, Hauss C, Reimund B, Goetz J, Kedinger C. Chatton B, et al. Mol Cell Biol. 1993 Jan;13(1):561-70. doi: 10.1128/mcb.13.1.561-570.1993. Mol Cell Biol. 1993. PMID: 8417352 Free PMC article. - Down-regulation of HLA antigens by the adenovirus type 2 E3/19K protein in a T-lymphoma cell line.
Körner H, Burgert HG. Körner H, et al. J Virol. 1994 Mar;68(3):1442-8. doi: 10.1128/JVI.68.3.1442-1448.1994. J Virol. 1994. PMID: 8107207 Free PMC article.
References
- Cell. 1983 Nov;35(1):137-48 - PubMed
- Cell. 1981 Feb;23(2):561-71 - PubMed
- Virology. 1983 Nov;131(1):49-58 - PubMed
- Mol Cell Biol. 1983 Nov;3(11):2058-65 - PubMed
- Mol Cell Biol. 1983 Dec;3(12):2131-42 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources