Antibodies to normal human melanocytes in vitiligo - PubMed (original) (raw)
Antibodies to normal human melanocytes in vitiligo
G K Naughton et al. J Exp Med. 1983.
Abstract
Most patients with active vitiligo (82% of 61) have antibodies to antigens of normal human melanocytes that can be detected by specific immunoprecipitation of radioiodinated, detergent-soluble, melanocyte macromolecules. Such antibodies were present in only 12% of patients with melanoma and in none of 35 patients with nonpigmentary skin diseases. The antibodies were directed to a common antigen(s) on melanocytes that was not present on normal fibroblasts or keratinocytes. These observations suggest that vitiligo is an autoimmune disease mediated by antibodies to melanocyte-associated antigen(s).
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References
- Biochemistry. 1971 May 11;10(10):1766-71 - PubMed
- Br J Dermatol. 1975 Apr;92(4):395-400 - PubMed
- N Engl J Med. 1977 Sep 22;297(12):634-7 - PubMed
- JAMA. 1978 Mar 20;239(12):1183-7 - PubMed
- Arch Dermatol. 1979 Mar;115(3):364 - PubMed
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