Effect of litter size on plasma cholesterol and insulin and some liver and adipose tissue enzymes in adult rodents - PubMed (original) (raw)
Effect of litter size on plasma cholesterol and insulin and some liver and adipose tissue enzymes in adult rodents
P Hahn. J Nutr. 1984 Jul.
Abstract
Rats and mice were raised in litters of 4 or 14 per mother. Plasma levels of cholesterol and insulin were found to be elevated later in life in those raised in small litters. Hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity in rats was higher in large than in small litters on day 60 but not on day 240. In adipose tissue activity was higher in the small litters. The activities of phosphoenolpyruvate carboxy-kinase in liver and of fatty acid synthetase in adipose tissue were higher in large than in small litters later in life. It is concluded that early quantitative changes in food intake have permanent late effects.
Similar articles
- Hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase response to litter size in suckling rats.
Hahn P, Walker BL. Hahn P, et al. Can J Biochem. 1979 Oct;57(10):1216-9. doi: 10.1139/o79-159. Can J Biochem. 1979. PMID: 396009 - Cholesterol synthesis in the small intestine and adipose tissue of suckling rats: the effect of litter size.
Kroeger S, Hahn P. Kroeger S, et al. Biol Neonate. 1983;44(2):123-8. doi: 10.1159/000241705. Biol Neonate. 1983. PMID: 6683975 - Effects of litter size and diet composition on the development of some lipogenic enzymes in the liver and brown adipose tissue of the rat.
Kostolansky IT, Angel JF. Kostolansky IT, et al. J Nutr. 1989 Nov;119(11):1709-15. doi: 10.1093/jn/119.11.1709. J Nutr. 1989. PMID: 2600677 - Phosphoenolpyruvate carboxykinase. II. Hormonal controls.
Hanson RW, Garber AJ, Reshef L, Ballard FJ. Hanson RW, et al. Am J Clin Nutr. 1973 Jan;26(1):55-63. doi: 10.1093/ajcn/26.1.55. Am J Clin Nutr. 1973. PMID: 4345515 Review. No abstract available.
Cited by
- Glucocorticoids contribute to metabolic and liver impairments induced by lactation overnutrition in male adult rats.
de Souza CF, Stopa LRS, Martins AB, Wunderlich ALM, Lopes GM, de Fatima Silva F, Komino ACM, Zaia DAM, Zaia CTBV, Lima FB, Uchoa ET. de Souza CF, et al. Front Physiol. 2023 May 10;14:1161582. doi: 10.3389/fphys.2023.1161582. eCollection 2023. Front Physiol. 2023. PMID: 37234421 Free PMC article. - Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence From a Chilean Infancy Cohort.
Von Holle A, North KE, Gahagan S, Blanco E, Burrows R, Lozoff B, Howard AG, Justice AE, Graff M, Voruganti S. Von Holle A, et al. Am J Epidemiol. 2022 Sep 28;191(10):1700-1709. doi: 10.1093/aje/kwac057. Am J Epidemiol. 2022. PMID: 35467716 Free PMC article. - Misadjustment of diurnal expression of core temperature and locomotor activity in lactating rabbits associated with maternal over-nutrition before and during pregnancy.
Navarrete E, Díaz-Villaseñor A, Díaz G, Salazar AM, Montúfar-Chaveznava R, Ostrosky-Wegman P, Caldelas I. Navarrete E, et al. PLoS One. 2020 May 8;15(5):e0232400. doi: 10.1371/journal.pone.0232400. eCollection 2020. PLoS One. 2020. PMID: 32384084 Free PMC article. - Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets.
Li G, Petkova TD, Laritsky E, Kessler N, Baker MS, Zhu S, Waterland RA. Li G, et al. Environ Epigenet. 2019 Aug 25;5(3):dvz015. doi: 10.1093/eep/dvz015. eCollection 2019 Jul. Environ Epigenet. 2019. PMID: 31528363 Free PMC article. - Postnatal induction of muscle fatty acid oxidation in mice differing in propensity to obesity: a role of pyruvate dehydrogenase.
Buresova J, Janovska P, Kuda O, Krizova J, der Stelt IR, Keijer J, Hansikova H, Rossmeisl M, Kopecky J. Buresova J, et al. Int J Obes (Lond). 2020 Jan;44(1):235-244. doi: 10.1038/s41366-018-0281-0. Epub 2018 Dec 11. Int J Obes (Lond). 2020. PMID: 30538280
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical