Therapeutic efficacy and tolerance of diclofensine in psychoreactive depression--a double-blind comparison with placebo

PMID: 6379345

Clinical Trial

O L Omer et al. Methods Find Exp Clin Pharmacol. 1984 Mar.

Abstract

Diclofensine increases the availability of the three neurotransmitters dopamine, noradrenaline and serotonin by inhibiting their re-uptake into synaptosomes. In a randomized double-blind parallel-group comparative study, a total of 40 patients, some hospitalized (n = 11) and some ambulatory (n = 29), mean age of 39.6 years +/- 12 S.D., with psychoreactive depression were treated for 30 days with 2 X 25 mg/day of diclofensine or with placebo. The assessments of efficacy indicated superiority of diclofensine over placebo. The number of "improved" patients (reduction in the overall depression scores by 50% or better) relative to that of "not improved" patients, was found to be statistically significant (p less than 0.025) on day 10 of treatment. With respect to individual symptoms, anxiety showed a significantly (p less than 0.05) better improvement under diclofensine than under placebo. Side effects were observed in one patient in each group. One patient (diclofensine group) reported a transient slight somnolence, the other (placebo group) reported episodes of transient dizziness. Based on these data it can be concluded that diclofensine is a well tolerated and effective drug for the treatment of symptoms associated with reactive depressions.

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Lamb RJ, Griffiths RR. Lamb RJ, et al. Psychopharmacology (Berl). 1990;102(2):183-90. doi: 10.1007/BF02245920. Psychopharmacology (Berl). 1990. PMID: 2125734

Therapeutic efficacy and tolerance of diclofensine in psychoreactive depression--a double-blind comparison with placebo - PubMed (original) (raw)