Mechanisms of mucosal invasion by pathogenic Neisseria - PubMed (original) (raw)
Review
Mechanisms of mucosal invasion by pathogenic Neisseria
Z A McGee et al. Rev Infect Dis. 1983 Sep-Oct.
Abstract
Neisseria gonorrhoeae are transported across the mucosa of human fallopian tubes in organ culture by mucosal cells. The steps in this process are (1) attachment of gonococci to microvilli of nonciliated cells, (2) phagocytosis of gonococci by these cells, (3) transport of phagocytic vacuoles containing gonococci to the base of the cell, and (4) exocytosis of gonococci with phagocytic vacuoles into the subepithelial tissues. In vivo gonococci in the subepithelial tissues may cause extensive local disease (e.g., salpingitis) or invade blood vessels to cause disseminated disease. Preliminary studies of human nasopharyngeal tissue in organ culture infected with Neisseria meningitidis indicate that meningococci attach to microvilli of nonciliated cells and are phagocytized by these cells. They subsequently appear in subepithelial tissues, but the route they take is not yet certain. These observations suggest that the mechanisms of attachment to and penetration of fallopian tube and nasopharyngeal mucosa by N. gonorrhoeae and N. meningitidis are similar or possibly identical.
Similar articles
- Attachment of pathogenic Neisseria to human mucosal surfaces: role in pathogenesis.
Stephens DS, McGee ZA, Melly MA, Hoffman LH, Gregg CR. Stephens DS, et al. Infection. 1982;10(3):192-5. doi: 10.1007/BF01640777. Infection. 1982. PMID: 6125478 - Cytopathic effects of the pathogenic Neisseria. Studies using human fallopian tube organ cultures and human nasopharyngeal organ cultures.
Stephens DS, McGee ZA, Cooper MD. Stephens DS, et al. Antonie Van Leeuwenhoek. 1987;53(6):575-84. doi: 10.1007/BF00415519. Antonie Van Leeuwenhoek. 1987. PMID: 3130794 - Common pathways of invasion of mucosal barriers by Neisseria gonorrhoeae and Neisseria meningitidis.
McGee ZA, Stephens DS. McGee ZA, et al. Surv Synth Pathol Res. 1984;3(1):1-10. Surv Synth Pathol Res. 1984. PMID: 6150544 Review. No abstract available. - Molecular mechanisms of pathogenicity of gonococcal salpingitis.
Woods ML 2nd, McGee ZA. Woods ML 2nd, et al. Drugs. 1986;31 Suppl 2:1-6. doi: 10.2165/00003495-198600312-00001. Drugs. 1986. PMID: 2873017
Cited by
- Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Lim KYL, Mullally CA, Haese EC, Kibble EA, McCluskey NR, Mikucki EC, Thai VC, Stubbs KA, Sarkar-Tyson M, Kahler CM. Lim KYL, et al. Antibiotics (Basel). 2021 Jan 21;10(2):103. doi: 10.3390/antibiotics10020103. Antibiotics (Basel). 2021. PMID: 33494538 Free PMC article. Review. - Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1.
Guvenc F, Kaul R, Gray-Owen SD. Guvenc F, et al. Front Microbiol. 2020 Jun 3;11:1299. doi: 10.3389/fmicb.2020.01299. eCollection 2020. Front Microbiol. 2020. PMID: 32582133 Free PMC article. Review. - Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis.
Barrett KF, Dranow DM, Phan IQ, Michaels SA, Shaheen S, Navaluna ED, Craig JK, Tillery LM, Choi R, Edwards TE, Conrady DG, Abendroth J, Horanyi PS, Lorimer DD, Van Voorhis WC, Zhang Z, Barrett LK, Subramanian S, Staker B, Fan E, Myler PJ, Soge OO, Hybiske K, Ojo KK. Barrett KF, et al. Protein Sci. 2020 Mar;29(3):768-778. doi: 10.1002/pro.3824. Epub 2020 Jan 28. Protein Sci. 2020. PMID: 31930578 Free PMC article. - Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube.
Lenz JD, Dillard JP. Lenz JD, et al. Front Immunol. 2018 Nov 21;9:2710. doi: 10.3389/fimmu.2018.02710. eCollection 2018. Front Immunol. 2018. PMID: 30524442 Free PMC article. Review. - The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.
Calmettes C, Ing C, Buckwalter CM, El Bakkouri M, Chieh-Lin Lai C, Pogoutse A, Gray-Owen SD, Pomès R, Moraes TF. Calmettes C, et al. Nat Commun. 2015 Aug 18;6:7996. doi: 10.1038/ncomms8996. Nat Commun. 2015. PMID: 26282243 Free PMC article.