Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome 2L in Drosophila melanogaster - PubMed (original) (raw)

PMID: 6418476
DOI: 10.1007/BF00292904

Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome 2L in Drosophila melanogaster

G Reuter et al. Chromosoma. 1983.

Abstract

Three suppressor loci for position-effect variegation, one dominant temperature-sensitive (DTS), three Minute genes, and two recessive visible mutants (ed, tkv) have been cytogenetically localized by using duplications and deficiencies in regions 23-25 of chromosome arm 2L of Drosophila melanogaster. Two of the suppressor loci studied proved to represent haplo-abnormal genes localized in regions 23A6-23F6 and 24E2-25A1, respectively. The third one is a strong triplo-abnormal suppressor mapping in 25F4-26B9 which affects white variegation in wm4h when present in three doses. The l(2)2DTS mutation, which belongs to a group of noncomplementing dominant temperature-sensitive mutations, is localized in the 25A4-B1 region. Furthermore, two Minute genes have been localized in region 24 that are included in Df(2L)M11 and can be separated employing translocation (Y;2)P8 (24E2-4): M(2)LS2 in 24D3-4-24E2-4, and M(2)z in 24E4-5-24F5-7. A third Minute gene (M(2)S1) is localized in 25C3-8-25C9-D1. The usefulness of the isolated chromosomal rearrangements for further genetic studies of region 23-26 is discussed.

PubMed Disclaimer

Cited by

Telomeric position effect--a third silencing mechanism in eukaryotes.
Doheny JG, Mottus R, Grigliatti TA. Doheny JG, et al. PLoS One. 2008;3(12):e3864. doi: 10.1371/journal.pone.0003864. Epub 2008 Dec 5. PLoS One. 2008. PMID: 19057646 Free PMC article.
HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila.
Greil F, de Wit E, Bussemaker HJ, van Steensel B. Greil F, et al. EMBO J. 2007 Feb 7;26(3):741-51. doi: 10.1038/sj.emboj.7601527. Epub 2007 Jan 25. EMBO J. 2007. PMID: 17255947 Free PMC article.
The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster.
Hearn MG, Hedrick A, Grigliatti TA, Wakimoto BT. Hearn MG, et al. Genetics. 1991 Aug;128(4):785-97. doi: 10.1093/genetics/128.4.785. Genetics. 1991. PMID: 1916244 Free PMC article.
The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes.
Tschiersch B, Hofmann A, Krauss V, Dorn R, Korge G, Reuter G. Tschiersch B, et al. EMBO J. 1994 Aug 15;13(16):3822-31. doi: 10.1002/j.1460-2075.1994.tb06693.x. EMBO J. 1994. PMID: 7915232 Free PMC article.
P transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster.
Dorn R, Szidonya J, Korge G, Sehnert M, Taubert H, Archoukieh E, Tschiersch B, Morawietz H, Wustmann G, Hoffmann G, et al. Dorn R, et al. Genetics. 1993 Feb;133(2):279-90. doi: 10.1093/genetics/133.2.279. Genetics. 1993. PMID: 8382174 Free PMC article.

References

1. Genetics. 1980 Mar;94(3):647-62 - PubMed
1. Hereditas. 1983;99(1):89-114 - PubMed
1. Genetics. 1979 Mar;91(3):421-41 - PubMed
1. Proc Natl Acad Sci U S A. 1969 Feb;62(2):369-76 - PubMed
1. Genetics. 1972 May;71(1):157-84 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Molecular Biology Databases
- FlyBase
Miscellaneous
- NCI CPTAC Assay Portal

Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome 2L in Drosophila melanogaster - PubMed (original) (raw)