Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes - PubMed (original) (raw)
Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes
S L Zipursky et al. Cell. 1984 Jan.
Abstract
The compound eye of D. melanogaster is a reiterative pattern of facets, each containing eight photoreceptor cells in a precise arrangement. This pattern is established in the eye imaginal disc during the third larval instar. A wave of morphogenesis sweeps from posterior to anterior across the disc, leaving in its wake organized clusters of photoreceptor cells. We have used monoclonal antibodies to highlight pattern elements that are not readily observable by other techniques. Monoclonal antibodies can be used to identify the molecules associated with particular patterns, providing links between observable structures and the genes. As an example, we present the purification and N-terminal sequence of a glycoprotein antigen specific to photoreceptor cells and their axons.
Similar articles
- Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina.
Renfranz PJ, Benzer S. Renfranz PJ, et al. Dev Biol. 1989 Dec;136(2):411-29. doi: 10.1016/0012-1606(89)90267-4. Dev Biol. 1989. PMID: 2511049 - Subcellular localization of transcripts in Drosophila photoreceptor neurons: chaoptic mutants have an aberrant distribution.
Pollock JA, Ellisman MH, Benzer S. Pollock JA, et al. Genes Dev. 1990 May;4(5):806-21. doi: 10.1101/gad.4.5.806. Genes Dev. 1990. PMID: 2143163 - Analysis of mutants in chaoptin, a photoreceptor cell-specific glycoprotein in Drosophila, reveals its role in cellular morphogenesis.
Van Vactor D Jr, Krantz DE, Reinke R, Zipursky SL. Van Vactor D Jr, et al. Cell. 1988 Jan 29;52(2):281-90. doi: 10.1016/0092-8674(88)90517-x. Cell. 1988. PMID: 2449286 - Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina.
Yamamoto D. Yamamoto D. Bioessays. 1994 Apr;16(4):237-44. doi: 10.1002/bies.950160406. Bioessays. 1994. PMID: 8031300 Review. - [Role of Crumbs proteins in the control of epithelial cell and photoreceptor morphogenesis].
Lemmers C, Médina E, Lane-Guermonprez L, Arsanto JP, Le Bivic A. Lemmers C, et al. Med Sci (Paris). 2004 Jun-Jul;20(6-7):663-7. doi: 10.1051/medsci/2004206-7663. Med Sci (Paris). 2004. PMID: 15329816 Review. French.
Cited by
- A Drosophila Model Reveals the Potential Role for mtt in Retinal Disease.
Chen W, Zhong W, Yu L, Lin X, Xie J, Liu Z. Chen W, et al. Int J Mol Sci. 2024 Jan 11;25(2):899. doi: 10.3390/ijms25020899. Int J Mol Sci. 2024. PMID: 38255972 Free PMC article. - miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model.
Deshpande P, Chen CY, Chimata AV, Li JC, Sarkar A, Yeates C, Chen CH, Kango-Singh M, Singh A. Deshpande P, et al. Cell Death Dis. 2024 Jan 18;15(1):71. doi: 10.1038/s41419-023-06361-3. Cell Death Dis. 2024. PMID: 38238337 Free PMC article. - SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration.
Singh A, Chimata AV, Deshpande P, Bajpai S, Sangeeth A, Rajput M, Singh A. Singh A, et al. Neural Regen Res. 2024 Jun 1;19(6):1385-1392. doi: 10.4103/1673-5374.382989. Epub 2023 Aug 14. Neural Regen Res. 2024. PMID: 37905889 Free PMC article. - N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
Deshpande P, Chimata AV, Snider E, Singh A, Kango-Singh M, Singh A. Deshpande P, et al. Cell Death Dis. 2023 Jul 28;14(7):478. doi: 10.1038/s41419-023-05973-z. Cell Death Dis. 2023. PMID: 37507384 Free PMC article. - Change in the graphics of journal articles in the life sciences field: analysis of figures and tables in the journal "Cell".
Ariga K, Tashiro M. Ariga K, et al. Hist Philos Life Sci. 2022 Aug 2;44(3):33. doi: 10.1007/s40656-022-00516-9. Hist Philos Life Sci. 2022. PMID: 35918565 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous