Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus - PubMed (original) (raw)
- PMID: 6420706
- DOI: 10.1038/307334a0
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
A C Hayday et al. Nature. 1984.
Abstract
A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin's lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q+ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.
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