N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor - PubMed (original) (raw)
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor
K Sestanj et al. J Med Chem. 1984 Mar.
No abstract available
Similar articles
- The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
Simard-Duquesne N, Greselin E, Dubuc J, Dvornik D. Simard-Duquesne N, et al. Metabolism. 1985 Oct;34(10):885-92. doi: 10.1016/0026-0495(85)90133-7. Metabolism. 1985. PMID: 3930915 - Inhibition of polyol pathway activity in diabetic and galactosemic rats by the aldose reductase inhibitor CP-45,634.
Peterson MJ, Sarges R, Aldinger CE, MacDonald DP. Peterson MJ, et al. Adv Exp Med Biol. 1979;119:347-56. doi: 10.1007/978-1-4615-9110-8_51. Adv Exp Med Biol. 1979. PMID: 115231 No abstract available. - Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
Wrobel J, Millen J, Sredy J, Dietrich A, Gorham BJ, Malamas M, Kelly JM, Bauman JG, Harrison MC, Jones LR, et al. Wrobel J, et al. J Med Chem. 1991 Aug;34(8):2504-20. doi: 10.1021/jm00112a029. J Med Chem. 1991. PMID: 1908522 - The medicinal chemistry of aldose reductase inhibitors.
Humber LG. Humber LG. Prog Med Chem. 1987;24:299-343. doi: 10.1016/s0079-6468(08)70425-9. Prog Med Chem. 1987. PMID: 3144023 Review. No abstract available. - Medicinal chemistry of aldose reductase inhibitors.
Larson ER, Lipinski CA, Sarges R. Larson ER, et al. Med Res Rev. 1988 Apr-Jun;8(2):159-86. doi: 10.1002/med.2610080202. Med Res Rev. 1988. PMID: 3132580 Review. No abstract available.
Cited by
- In Search of Differential Inhibitors of Aldose Reductase.
Balestri F, Moschini R, Mura U, Cappiello M, Del Corso A. Balestri F, et al. Biomolecules. 2022 Mar 22;12(4):485. doi: 10.3390/biom12040485. Biomolecules. 2022. PMID: 35454074 Free PMC article. Review. - Chemical Aspects of Human and Environmental Overload with Fluorine.
Han J, Kiss L, Mei H, Remete AM, Ponikvar-Svet M, Sedgwick DM, Roman R, Fustero S, Moriwaki H, Soloshonok VA. Han J, et al. Chem Rev. 2021 Apr 28;121(8):4678-4742. doi: 10.1021/acs.chemrev.0c01263. Epub 2021 Mar 16. Chem Rev. 2021. PMID: 33723999 Free PMC article. Review. - Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity.
Thiagarajan R, Varsha MKNS, Srinivasan V, Ravichandran R, Saraboji K. Thiagarajan R, et al. Sci Rep. 2019 Oct 11;9(1):14684. doi: 10.1038/s41598-019-51059-2. Sci Rep. 2019. PMID: 31604989 Free PMC article. - Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation.
Castellví A, Crespo I, Crosas E, Cámara-Artigas A, Gavira JA, Aranda MAG, Parés X, Farrés J, Juanhuix J. Castellví A, et al. Sci Rep. 2019 Feb 28;9(1):3177. doi: 10.1038/s41598-019-39722-0. Sci Rep. 2019. PMID: 30816220 Free PMC article. - Cataract as Early Ocular Complication in Children and Adolescents with Type 1 Diabetes Mellitus.
Šimunović M, Paradžik M, Škrabić R, Unić I, Bućan K, Škrabić V. Šimunović M, et al. Int J Endocrinol. 2018 Mar 20;2018:6763586. doi: 10.1155/2018/6763586. eCollection 2018. Int J Endocrinol. 2018. PMID: 29755521 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Chemical Information