A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes - PubMed (original) (raw)
Comparative Study
A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes
B K Suarez et al. Am J Med Genet. 1984 May.
Abstract
Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method.
Similar articles
- Power of the affected-sib-pair method to defect disease susceptibility loci of small effect: an application to multiple sclerosis.
Suarez B, O'Rourke D, Van Eerdewegh P. Suarez B, et al. Am J Med Genet. 1982 Jul;12(3):309-26. doi: 10.1002/ajmg.1320120309. Am J Med Genet. 1982. PMID: 6956238 - Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis.
Harbo HF, Lie BA, Sawcer S, Celius EG, Dai KZ, Oturai A, Hillert J, Lorentzen AR, Laaksonen M, Myhr KM, Ryder LP, Fredrikson S, Nyland H, Sørensen PS, Sandberg-Wollheim M, Andersen O, Svejgaard A, Edland A, Mellgren SI, Compston A, Vartdal F, Spurkland A. Harbo HF, et al. Tissue Antigens. 2004 Mar;63(3):237-47. doi: 10.1111/j.0001-2815.2004.00173.x. Tissue Antigens. 2004. PMID: 14989713 - Presumptive evidence for an immunosuppressor susceptibility gene, linked to HLA, in rheumatic fever.
Hafez M, el-Shennawy F, el-Ziny M, Abo-el-Hasan S, Khashaba M. Hafez M, et al. Dis Markers. 1987 Sep;5(3):177-85. Dis Markers. 1987. PMID: 2971499 - Testing linkage and gene x environment interaction: comparison of different affected sib-pair methods.
Dizier MH, Selinger-Leneman H, Genin E. Dizier MH, et al. Genet Epidemiol. 2003 Jul;25(1):73-9. doi: 10.1002/gepi.10244. Genet Epidemiol. 2003. PMID: 12813728 Review. - [Immunology in medical practice. XXVI. Immunogenetics of chronic inflammatory bowel diseases].
Bouma G, Peña AS. Bouma G, et al. Ned Tijdschr Geneeskd. 1999 Nov 27;143(48):2414-20. Ned Tijdschr Geneeskd. 1999. PMID: 10608975 Review. Dutch.
Cited by
- Genome scan for human obesity and linkage to markers in 20q13.
Lee JH, Reed DR, Li WD, Xu W, Joo EJ, Kilker RL, Nanthakumar E, North M, Sakul H, Bell C, Price RA. Lee JH, et al. Am J Hum Genet. 1999 Jan;64(1):196-209. doi: 10.1086/302195. Am J Hum Genet. 1999. PMID: 9915959 Free PMC article. - Analysis of affected sib pairs, with covariates--with and without constraints.
Greenwood CM, Bull SB. Greenwood CM, et al. Am J Hum Genet. 1999 Mar;64(3):871-85. doi: 10.1086/302288. Am J Hum Genet. 1999. PMID: 10053022 Free PMC article. - Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data.
Abel L, Müller-Myhsok B. Abel L, et al. Am J Hum Genet. 1998 Aug;63(2):638-47. doi: 10.1086/301958. Am J Hum Genet. 1998. PMID: 9683590 Free PMC article. - Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.
Schwab SG, Hallmayer J, Lerer B, Albus M, Borrmann M, Hönig S, Strauss M, Segman R, Lichtermann D, Knapp M, Trixler M, Maier W, Wildenauer DB. Schwab SG, et al. Am J Hum Genet. 1998 Oct;63(4):1139-52. doi: 10.1086/302046. Am J Hum Genet. 1998. PMID: 9758604 Free PMC article. - Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.
Wallace C, Xue MZ, Newhouse SJ, Marcano AC, Onipinla AK, Burke B, Gungadoo J, Dobson RJ, Brown M, Connell JM, Dominiczak A, Lathrop GM, Webster J, Farrall M, Mein C, Samani NJ, Caulfield MJ, Clayton DG, Munroe PB. Wallace C, et al. Am J Hum Genet. 2006 Aug;79(2):323-31. doi: 10.1086/506370. Epub 2006 Jun 19. Am J Hum Genet. 2006. PMID: 16826522 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials