Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines - PubMed (original) (raw)
. 1984 Dec;44(12 Pt 1):5657-60.
- PMID: 6437672
Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines
S D Smith et al. Cancer Res. 1984 Dec.
Abstract
Recently, four distinct cell lines were established from patients whose malignancies had been defined by immunological and biochemical markers. Each patient had a distinct subtype of a T-cell cancer, and each possessed elevated adenosine deaminase and reduced nucleoside phosphorylase activity. Cell lines cultured in vitro possessed the same basic immunophenotype and biochemical enzyme activity as the patients' original malignant cells. In a direct comparison of the immunophenotype of the cell lines and the patients' malignant cells, full concordance existed for 48 of 52 paired antibody tests performed. However, when compared to the corresponding patient's sample, each cell line showed some minor changes in antigen expression or enzyme level. Antigen loss, de novo antigen expression, or elevated adenosine deaminase levels occurred in the cell lines, and these changes were stable on repeated analysis. While there was good general concordance between the patient's cancer and the established cell line, minor biological differences in the cell lines may reflect cellular maturation or subpopulation selection in vitro.
Similar articles
- Enzymes of purine metabolism and membrane phenotype in malignant cells of some leukemia patients.
Babusíková O, Hrivnáková A, Pechán I, Ujházy P. Babusíková O, et al. Neoplasma. 1984;31(6):661-6. Neoplasma. 1984. PMID: 6441124 - Adenosine deaminase positive, E receptor negative lymphoma.
Gordon EM, Gross S, Altman A. Gordon EM, et al. Am J Pediatr Hematol Oncol. 1982 Summer;4(2):135-9. Am J Pediatr Hematol Oncol. 1982. PMID: 6981356 - [Biological and immunological markers in acute leukaemia (author's transl)].
López Borrasca A, González M, Hernández F, Ledesma M, Corrales A, San Miguel J. López Borrasca A, et al. Sangre (Barc). 1981;26(5B):756-82. Sangre (Barc). 1981. PMID: 6275558 Review. Spanish. No abstract available. - [Biochemical markers in lymphatic neoplasms].
Ho AD, Dörken B, Hunstein W. Ho AD, et al. Dtsch Med Wochenschr. 1984 Sep 7;109(36):1375-8. doi: 10.1055/s-2008-1069382. Dtsch Med Wochenschr. 1984. PMID: 6088206 Review. German. No abstract available.
Cited by
- The Disassociation of A3G-Related HIV-1 cDNA G-to-A Hypermutation to Viral Infectivity.
Martin J, Chen X, Jia X, Shao Q, Liu B. Martin J, et al. Viruses. 2024 May 4;16(5):728. doi: 10.3390/v16050728. Viruses. 2024. PMID: 38793610 Free PMC article. - HIV-1 3'-Polypurine Tract Mutations Confer Dolutegravir Resistance by Switching to an Integration-Independent Replication Mechanism via 1-LTR Circles.
Dekker JG, Klaver B, Berkhout B, Das AT. Dekker JG, et al. J Virol. 2023 May 31;97(5):e0036123. doi: 10.1128/jvi.00361-23. Epub 2023 May 1. J Virol. 2023. PMID: 37125907 Free PMC article. - Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14+ Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines.
Hoffman HK, Aguilar RS, Clark AR, Groves NS, Pezeshkian N, Bruns MM, van Engelenburg SB. Hoffman HK, et al. J Virol. 2022 Jul 27;96(14):e0076722. doi: 10.1128/jvi.00767-22. Epub 2022 Jun 30. J Virol. 2022. PMID: 35770989 Free PMC article. - Transient CRISPR-Cas Treatment Can Prevent Reactivation of HIV-1 Replication in a Latently Infected T-Cell Line.
Liu Y, Jeeninga RE, Klaver B, Berkhout B, Das AT. Liu Y, et al. Viruses. 2021 Dec 8;13(12):2461. doi: 10.3390/v13122461. Viruses. 2021. PMID: 34960730 Free PMC article. - Topoisomerase II β Gene Specific siRNA Delivery by Nanoparticles Prepared with c-ter Apotransferrin and its Effect on HIV-1 Replication.
Sunnam LBK, Kondapi AK. Sunnam LBK, et al. Mol Biotechnol. 2021 Aug;63(8):732-745. doi: 10.1007/s12033-021-00334-7. Epub 2021 May 16. Mol Biotechnol. 2021. PMID: 33993458
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Research Materials