[Free and sulfo-conjugated dehydroepiandrosterone in the brain of mice with myelin biosynthesis disorders] - PubMed (original) (raw)

. 1981 Jan 12;292(2):231-4.

[Article in French]

[Free and sulfo-conjugated dehydroepiandrosterone in the brain of mice with myelin biosynthesis disorders]

[Article in French]

C Corpéchot et al. C R Seances Acad Sci III. 1981.

Abstract

Dehydroepiandrosterone, either unconjugated (D) or conjugated to sulfuric acid (DS), has been identified in the brain of male Mice; DS had been previously found in Rat brain. DS amounts in posterior brain, were 0.8-2.0 ng/g in controls, and very much lower in dysmyelinic jimpy and quaking Mice of the same age. Conversely, amounts of D were increased in affected Mice, suggesting an impaired sulfoconjugation. Results may be explained by accumulation of D and DS in brain, unrelated to the endocrine system.

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