Cloning and complete nucleotide sequence of human 5'-alpha-globin gene - PubMed (original) (raw)

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene

S A Liebhaber et al. Proc Natl Acad Sci U S A. 1980 Dec.

Abstract

We have cloned one of the two human alpha-globin genes and report its complete nucleotide sequence. The gene is 832 base pairs (bp) long from the 5'-cap site to the 3'-polyadenylylation site. The amino acid coding sequences are separated into three segments (exons) by two short (117 and 140 bp) intervening sequences. Highly conserved regions are identified in the 5'-flanking region, intron-exon junctions, and 3' noncoding regions that may have functional significance.

PubMed Disclaimer

References

    1. Biochemistry. 1967 Jun;6(6):1818-27 - PubMed
    1. Eur J Biochem. 1973 Jul 2;36(1):32-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Feb;72(2):737-41 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):784-8 - PubMed

MeSH terms

Substances

LinkOut - more resources