Aluminum-induced neurofibrillary changes in axons and dendrites - PubMed (original) (raw)

• PMID: 6464675
• DOI: 10.1007/BF00685244

Aluminum-induced neurofibrillary changes in axons and dendrites

H M Wisniewski et al. Acta Neuropathol. 1984.

Abstract

We examined the chronic effect of aluminum on the rabbit central nervous system (CNS) and documented the occurrence of axonal swellings (spheroids) and dendritic thickening in spinal cord neurons in addition to the accumulation of neurofibrillary material in the perikaryon. The axonal swellings always occurred at the first heminode, and the neurofilaments appeared disorganized, whereas in dendrites the neurofilaments generally retained their longitudinal arrangements. Although neurofibrillary tangles were present in cortical neurons, no axonal swellings were observed. Thickening of segments of apical dendrites proximal to the cell body affected by neurofibrillary changes was present. The axonal swellings resembled those observed in IDPN intoxication, and in amyotrophic lateral sclerosis, and may be useful as a model for studying these diseases.

PubMed Disclaimer

Similar articles

• Aluminum chloride induced neurofibrillary changes in the developing rabbit a chronic animal model.
  Wisniewski HM, Sturman JA, Shek JW. Wisniewski HM, et al. Ann Neurol. 1980 Nov;8(5):479-90. doi: 10.1002/ana.410080505. Ann Neurol. 1980. PMID: 7192069
• Chronic model of neurofibrillary changes induced in mature rabbits by metallic aluminum.
  Wisniewski HM, Sturman JA, Shek JW. Wisniewski HM, et al. Neurobiol Aging. 1982 Spring;3(1):11-22. doi: 10.1016/0197-4580(82)90056-2. Neurobiol Aging. 1982. PMID: 7099362
• Unusual neurofibrillary accumulations induced by beta,beta'-iminodipropionitrile (IDPN).
  Fiori MG, Lowndes HE. Fiori MG, et al. J Submicrosc Cytol Pathol. 1988 Jan;20(1):137-46. J Submicrosc Cytol Pathol. 1988. PMID: 2836049
• The association of aluminum Alzheimer's disease, and neurofibrillary tangles.
  Perl DP, Good PF. Perl DP, et al. J Neural Transm Suppl. 1987;24:205-11. J Neural Transm Suppl. 1987. PMID: 3316495 Review.
• Aluminum and neurodegenerative disease: therapeutic implications.
  McLachlan DR, Kruck TP, VanBerkum MF. McLachlan DR, et al. Am J Kidney Dis. 1985 Nov;6(5):322-9. doi: 10.1016/s0272-6386(85)80088-3. Am J Kidney Dis. 1985. PMID: 2865894 Review. No abstract available.

Cited by

• Immunocytochemical and ultrastructural evidence of dendritic degeneration in motor neurons of aluminum-intoxicated rabbits.
  Wakayama I, Nerurkar VR, Garruto RM. Wakayama I, et al. Acta Neuropathol. 1993;85(2):122-8. doi: 10.1007/BF00227758. Acta Neuropathol. 1993. PMID: 8442404
• Neurofilament degradation in the nervous system of rats intoxicated with acrylamide, related compounds or 2,5-hexanedione.
  Tanii H, Hayashi M, Hashimoto K. Tanii H, et al. Arch Toxicol. 1988 Aug;62(1):70-5. doi: 10.1007/BF00316261. Arch Toxicol. 1988. PMID: 3190460
• The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
  Gibb WR, Lees AJ. Gibb WR, et al. J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52. doi: 10.1136/jnnp.51.6.745. J Neurol Neurosurg Psychiatry. 1988. PMID: 2841426 Free PMC article. Review.
• Aluminum neurotoxicity in mammals.
  Wisniewski HM, Moretz RC, Sturman JA, Wen GY, Shek JW. Wisniewski HM, et al. Environ Geochem Health. 1990 Mar;12(1-2):115-20. doi: 10.1007/BF01734060. Environ Geochem Health. 1990. PMID: 24202577

References

1. 1. Ann Neurol. 1982 Sep;12(3):278-83 - PubMed
2. 1. Neuropediatrics. 1982 Aug;13(3):123-9 - PubMed
3. 1. Acta Neuropathol. 1967 Oct 20;9(2):127-33 - PubMed
4. 1. J Ultrastruct Res. 1969 Jan;26(1):31-43 - PubMed
5. 1. Neurobiol Aging. 1982 Fall;3(3):209-22 - PubMed

Publication types

MeSH terms

Substances